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  本文關(guān)鍵詞：阿呋唑嗪和坦索羅辛對輸尿管結(jié)石的臨床療效研究　出處：《中國臨床藥理學雜志》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： 輸尿管結(jié)石 坦索羅辛 阿呋唑嗪

【摘要】：目的觀察α受體阻滯藥阿呋唑嗪和坦索羅辛對輸尿管結(jié)石的臨床療效和安全性。方法 320例確診為輸尿管結(jié)石的患者隨機分為試驗組和對照組,各160例。試驗組口服鹽酸阿呋唑嗪緩釋片,每次10 mg,每天1次,對照組口服鹽酸坦索羅辛緩釋膠囊,每次0.4 mg,每天1次,2組療程均為4周。所有患者在治療期間保持每日飲水2000~3000 m L。記錄每例患者的結(jié)石位置、大小等,每位患者臨床檢查結(jié)石排出,或者經(jīng)過臨床醫(yī)師會診需要改為手術(shù)治療的為記錄和研究結(jié)束點。結(jié)果試驗組結(jié)石排出率為63.13%,結(jié)石排出時間為(9.43±1.34)d;對照組結(jié)石排出率為76.25%,結(jié)石排出時間為(8.48±1.66)d,差異有統(tǒng)計意義(P0.05)。試驗組輸尿管上、中、下段結(jié)石排出率分別為53.85%,60.87%,65.77%,對照組分別為52.38%,62.92%,83.93%;試驗組上、中、下段結(jié)石排出時間(9.50±1.22),(9.14±1.35),(9.48±1.37)d,對照組分別為(9.45±1.44),(8.76±1.03),(8.32±1.74)d,試驗組和對照組輸尿管上段和中段結(jié)石的排出率與排石時間差異無統(tǒng)計學意義(P0.05),下段結(jié)石排出率和排出時間差異有統(tǒng)計學意義(P0.05)。結(jié)論坦索羅辛和阿呋唑嗪對輸尿管上段和中段的結(jié)石排出率及排出時間無明顯差異,對輸尿管下段結(jié)石,坦索羅辛優(yōu)于阿呋唑嗪。
[Abstract]:Objective to observe the clinical efficacy and safety of 偽 -receptor blockers alfuzosin and tamsoloxine in the treatment of ureteral calculi. Methods 320 patients with ureteral calculi were randomly divided into two groups: the experimental group and the control group. Each 160 cases were treated with alfuzosin hydrochloride sustained-release tablets once a day, and the control group with 0.4 mg of tansuloxine hydrochloride sustained-release capsules once a day. The course of treatment in both groups was 4 weeks. During the treatment period, all the patients maintained drinking water of 2000m / L daily. The location and size of the stones were recorded in each patient, and the stones were excreted from each patient by clinical examination. Results in the test group, the stone excretion rate was 63.13 and the time of stone excretion was 9.43 鹵1.34 days. In the control group, the stone excretion rate was 76.25, and the stone excretion time was 8.48 鹵1.66 days. The difference was statistically significant (P 0.05). The excretion rate of stones in the lower segment was 53.85 and 60.87, respectively, and that in the control group was 52.38 and 62.92respectively, and 83.93 in the control group. In the test group, the time of excretion of stones in the middle and lower segments was 9.50 鹵1.22, 9.14 鹵1.35 and 9.48 鹵1.37 days, respectively, and that in the control group was 9.45 鹵1.44). The excretion rate of upper and middle ureteral calculi in the test group and the control group was not significantly different from that in the control group (P 0.05). Conclusion there is no significant difference between tamsoloxine and alfuzosin in the upper and middle ureteral calculi excretion rate and time. For lower ureteral calculi, tamsoloxine is superior to alfuzosin.
【作者單位】： 新疆醫(yī)科大學第一附屬醫(yī)院藥學部;新疆醫(yī)科大學第一附屬醫(yī)院泌尿中心;
【基金】：新疆醫(yī)科大學第一附屬醫(yī)院藥學專項基金資助項目(No.2012YX05)
【分類號】：R693.4
【正文快照】： 向云霞1a,劉冰1a,安恒慶1b,彭紅玉1a(1.新疆醫(yī)科大學第一附屬醫(yī)院,a.藥學部;b.泌尿中心,烏魯木齊830011)XIANG Yun-xia1a,LIU Bing1a,AN Heng-qing1b,PENG Hong-yu1a(1.a.Department of Pharmacy;b.Urology Center,The First TeachingHospital of Xinjiang MedicalUniversity,

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