本文選題：血漿可溶性血管內(nèi)皮生長(zhǎng)因子受體 + 重癥肺炎�。� 參考：《鄭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年01期

【摘要】：目的:探討血漿可溶性血管內(nèi)皮生長(zhǎng)因子受體1(s FLT-1)在重癥肺炎患者中的變化及預(yù)測(cè)價(jià)值。方法:選取2013年10月至2016年4月入住鄭州大學(xué)附屬鄭州中心醫(yī)院呼吸重癥醫(yī)學(xué)科的重癥肺炎患者60例(A組)、重癥肺炎合并感染性休克患者60例(B組)、重癥肺炎合并MODS患者60例(C組),選取同期入住呼吸內(nèi)科的社區(qū)獲得性肺炎患者60例作為對(duì)照組(D組)。比較各組患者入院第1、3、7天以及存活組(n=96)和死亡組(n=84)s FLT-1水平變化,分析血漿s FLT-1在重癥肺炎中的預(yù)測(cè)價(jià)值及與APACHEⅡ評(píng)分的相關(guān)性。結(jié)果:4組患者PCT和APACHEⅡ評(píng)分比較,差異有統(tǒng)計(jì)學(xué)意義(P均0.05)。A、B、C 3組患者血漿s FLT-1水平比較,差異有統(tǒng)計(jì)學(xué)意義,且A、B、C 3組第7天均低于第1天(P均0.05)。重癥肺炎死亡組s FLT-1水平高于存活組(P0.001)。重癥肺炎患者s FLT-1水平和APACHEⅡ評(píng)分有關(guān)(r=0.647,P0.001)。s FLT-1預(yù)測(cè)重癥肺炎和28 d病死率的敏感度及特異度分別為77.8%、75.0%和69.7%、80.1%,AUC分別為0.787(95%CI=72.6%~84.8%,P0.001)和0.775(95%CI=70.5%~84.5%,P0.001)。結(jié)論:血漿s FLT-1水平可以預(yù)測(cè)重癥肺炎和28 d病死率。
[Abstract]:Aim: to investigate the changes and predictive value of soluble vascular endothelial growth factor receptor (sVEGF) FLT 1 in patients with severe pneumonia. Methods: from October 2013 to April 2016, 60 severe pneumonia patients admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University, 60 patients with severe pneumonia complicated with septic shock, 60 patients with severe pneumonia with septic shock, and 60 patients with severe pneumonia combined with severe pneumonia were selected. 60 patients with MODS and 60 patients with community-acquired pneumonia who were admitted to respiratory medicine department were selected as control group. The changes of plasma s FLT-1 in patients with severe pneumonia and the correlation with APACHE 鈪，

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