目的探討抵抗素299G/A、PPARγPro12Ala基因多態(tài)性與GDM的相關(guān)性。方法選取156例GDM孕婦為GDM組和180名正常對(duì)照（NC）孕婦為NC組,采用聚合酶鏈反應(yīng)-限制性內(nèi)切酶技術(shù)（PCR-RFLP）對(duì)基因多態(tài)性進(jìn)行檢測(cè)。結(jié)果 GDM、NC組抵抗素299G/A基因型頻率GG∶GA∶AA分別為41.3%∶46.3%∶11.6%、35.2%∶51.7%∶13.8%,PPARγPro12Ala基因型頻率PP∶PA∶AA分別為92.3%∶7.7%∶0.0%、85.0%∶13.3%∶1.7%,兩組間基因型和等位基因頻率比較差異均無(wú)統(tǒng)計(jì)學(xué)意義。GDM組抵抗素基因GA、AA基因型孕婦FIns、胰島素抵抗指數(shù)（HOMA-IR）高于GG基因型[（12.99±9.98）vs（8.06±2.25）mU/L,（18.35±6.32）vs（8.06±2.25）mU/L;（2.45±0.96）vs（1.31±0.36）,（3.45±1.89）vs（1.31±0.36）,P<0.05]。PPARγ基因PP基因型孕婦BMI高于PA基因型[（29.47±1.68）vs（23.89±2.88）kg/m2... 

【文章來(lái)源】：中國(guó)糖尿病雜志. 2015,23(04)北大核心CSCD

【文章頁(yè)數(shù)】：4 頁(yè)

【文章目錄】：
對(duì)象與方法
    一、研究對(duì)象
    二、研究對(duì)象
    三、統(tǒng)計(jì)學(xué)方法
結(jié)果
    一、兩組不同基因型一般資料及生化資料比較
    二、兩組基因型和等位基因頻率分布比較
    三、GDM發(fā)病影響 因素的Logistic多元回歸 分析
討論


【參考文獻(xiàn)】：
期刊論文
[1]Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk:a case-control study of a Chinese Han population[J]. Juan Du a ,Hui Shi a ,Ying Lu a , Wencong Du a ,Yuanyuan Cao a , Qian Li b , Jianhua Ma b , Xinhua Ye c , Jinluo Cheng c , Xiaofang Yu d , Yanqin Gao d , Ling Zhou a* a Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China; b Department of Endocrinology, the Affiliated Nanjing First Hospital of Nanjing Medical University, Nanjing, Jiangsu 210006, China; c Department of Endocrinology, the Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, China; d Department of Endocrinology, the Affiliated Yizheng Third Hospital of Nanjing Medical University, Yizheng, Jiangsu, 211900 China..  Journal of Biomedical Research. 2011(01)



本文編號(hào)：3491628