目的:研究GDM孕婦與正常孕婦血清MDA、SOD及GSH水平變化,探索它們與GDM之間的相互關(guān)系,追蹤各組妊娠結(jié)局研究其臨床意義。方法:選取175例孕婦為研究對(duì)象,分為GDM組（93例）和對(duì)照組（82例）。采用微量法測(cè)定血清丙二醛（MDA）、谷胱甘肽（GSH）及超氧化物歧化酶（SOD）水平,并對(duì)妊娠結(jié)局進(jìn)行相關(guān)性分析。結(jié)果:（1） GDM組年齡、孕前體重、BMI值均高于對(duì)照組,GSH和SOD水平均低于對(duì)照組,MDA水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;（2） GDM組MDA水平與孕前體重呈負(fù)相關(guān)（r=-0.3547,P<0.05）,SOD水平與新生兒出生體重呈正相關(guān)（r=0.3292,P<0.05）,SOD值與早產(chǎn)之間有密切聯(lián)系（足月產(chǎn)12.68±0.85 vs.早產(chǎn)8.08±1.18, P <0.05）,GSH、SOD水平與孕前體重之間,MDA、GSH水平與新生兒出生體重之間,MDA、GSH水平與早產(chǎn)之間均無明顯相關(guān)性（P>0.05）,MDA、GSH和SOD水平與剖宮產(chǎn)及胎膜早破均無明顯相關(guān)性（P>0.05）。結(jié)論:GDM存在明顯的氧化... 

【文章來源】：現(xiàn)代生物醫(yī)學(xué)進(jìn)展. 2019,19(01)

【文章頁數(shù)】：6 頁

【部分圖文】：

GDM組與對(duì)照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewas

SOD水平在大于胎齡兒中是顯著增加的。這些數(shù)據(jù)都證明在巨大兒中確實(shí)存在氧化應(yīng)激失衡[20]。本研究并沒有發(fā)現(xiàn)MDA水平與新生兒出生體重有關(guān)系，這與我們預(yù)期結(jié)果并不相符，因?yàn)檫^去的一項(xiàng)研究證明患有宮內(nèi)生長(zhǎng)發(fā)育遲緩（IUGR）的孕婦，其圖1GDM組與對(duì)照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對(duì)照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對(duì)照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·

圖1GDM組與對(duì)照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對(duì)照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對(duì)照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·


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