妊娠期糖尿病患者氧化應激水平變化及臨床意義
發(fā)布時間：2021-06-15 23:50
目的:研究GDM孕婦與正常孕婦血清MDA、SOD及GSH水平變化,探索它們與GDM之間的相互關系,追蹤各組妊娠結局研究其臨床意義。方法:選取175例孕婦為研究對象,分為GDM組（93例）和對照組（82例）。采用微量法測定血清丙二醛（MDA）、谷胱甘肽（GSH）及超氧化物歧化酶（SOD）水平,并對妊娠結局進行相關性分析。結果:（1） GDM組年齡、孕前體重、BMI值均高于對照組,GSH和SOD水平均低于對照組,MDA水平高于對照組,差異有統(tǒng)計學意義（P<0.05）;（2） GDM組MDA水平與孕前體重呈負相關（r=-0.3547,P<0.05）,SOD水平與新生兒出生體重呈正相關（r=0.3292,P<0.05）,SOD值與早產之間有密切聯(lián)系（足月產12.68±0.85 vs.早產8.08±1.18, P <0.05）,GSH、SOD水平與孕前體重之間,MDA、GSH水平與新生兒出生體重之間,MDA、GSH水平與早產之間均無明顯相關性（P>0.05）,MDA、GSH和SOD水平與剖宮產及胎膜早破均無明顯相關性（P>0.05）。結論:GDM存在明顯的氧化...
【文章來源】：現(xiàn)代生物醫(yī)學進展. 2019,19(01)
【文章頁數(shù)】：6 頁
【部分圖文】：
GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewas
SOD水平在大于胎齡兒中是顯著增加的。這些數(shù)據(jù)都證明在巨大兒中確實存在氧化應激失衡[20]。本研究并沒有發(fā)現(xiàn)MDA水平與新生兒出生體重有關系，這與我們預期結果并不相符，因為過去的一項研究證明患有宮內生長發(fā)育遲緩（IUGR）的孕婦，其圖1GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
圖1GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
本文編號：3231940
【文章來源】：現(xiàn)代生物醫(yī)學進展. 2019,19(01)
【文章頁數(shù)】：6 頁
【部分圖文】：
GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewas
SOD水平在大于胎齡兒中是顯著增加的。這些數(shù)據(jù)都證明在巨大兒中確實存在氧化應激失衡[20]。本研究并沒有發(fā)現(xiàn)MDA水平與新生兒出生體重有關系，這與我們預期結果并不相符，因為過去的一項研究證明患有宮內生長發(fā)育遲緩（IUGR）的孕婦，其圖1GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
圖1GDM組與對照組MDA水平變化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.圖2GDM組與對照組GSH水平變化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.圖3GDM組與對照組SOD水平變化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
本文編號：3231940
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