【摘要】：目的探討體外受精-胚胎移植(IVF-ET)與單胎妊娠早產(chǎn)風(fēng)險(xiǎn)的關(guān)系。方法選取2012年1月至2013年1月行IVF-ET并于北京大學(xué)第三醫(yī)院助孕且分娩的單胎妊娠孕婦563例為研究組,其中女性因素不孕組(單純女性因素或合并雙方因素)369例、單純男性因素不孕組150例,44例不明原因不孕;按年齡、孕產(chǎn)次配對(duì)同一時(shí)間段自然單胎妊娠的1126例孕婦為對(duì)照組,分析兩組產(chǎn)科結(jié)局。結(jié)果研究組早產(chǎn)率顯著高于對(duì)照組(11.90%vs.6.93%,P0.05),妊娠期糖尿病、胎膜早破、前置胎盤、產(chǎn)后出血的發(fā)生率顯著高于對(duì)照組,新生兒出生孕周顯著低于對(duì)照組[(38.64±2.16)周vs.(39.12±1.73)周,P0.05],低出生體重發(fā)生率顯著高于對(duì)照組(8.34%vs.4.35%,P0.05)。女性因素不孕組早產(chǎn)率顯著高于單純男性因素不孕組及對(duì)照組(12.74%vs.6.67%vs.6.93%,P0.05);胎膜早破、產(chǎn)后出血發(fā)生率顯著高于單純男性因素不孕組(28.7%vs.11.33%,14.63%vs.6.67%,P0.05),妊娠期糖尿病、胎盤早破、前置胎盤、產(chǎn)后出血發(fā)生率顯著高于對(duì)照組(P0.05);女性因素不孕組新生兒出生孕周顯著低于單純男性因素不孕組及對(duì)照組[(38.51±2.15)周vs.(38.97±1.85)周vs.(38.64±2.16)周,P0.05)],低出生體重發(fā)生率顯著高于對(duì)照組(8.94%vs.4.35%,P0.05)。結(jié)論體外受精-胚胎移植患者單胎妊娠早產(chǎn)發(fā)生率增加,可能與引起女性不孕因素相關(guān)疾病及女性因素不孕婦女妊娠期并發(fā)癥發(fā)生率增加相關(guān)。
[Abstract]:Objective To study the relationship between in vitro fertilization and embryo transfer (IVF-ET) and the risk of preterm birth in single pregnancy. Methods From January 2012 to January 2013,563 cases of single-birth pregnant women who underwent IVF-ET in the third hospital of Beijing University and delivered in the third hospital of Beijing University were studied. There were 150 cases of single-male infertility,44 cases of unexplained infertility, and 1126 pregnant women who had a single pregnancy in the same time period according to the age and the same time period as the control group, and analyzed the two groups of obstetric outcomes. Results The rate of premature birth of the study group was significantly higher than that of the control group (11.90% vs. 6.93%, P0.05), and the incidence of gestational diabetes, premature rupture of the fetal membrane, preplacenta and postpartum hemorrhage was significantly higher than that of the control group (38.64 (2.16) weeks vs. (39.12, 1.73) weeks (P0.05). The incidence of low birth weight was significantly higher in the control group (8.34% vs. 4.35%, P0.05). The rate of premature birth in the female infertility group was significantly higher than that of the control group (12.74% vs. 6.67% vs. 6.93%, P0.05), and the incidence of postpartum hemorrhage was significantly higher than that of the single-male infertility group (28.7% vs. 11.33%, 14.63% vs. 6.67%, P0.05), gestational diabetes, placental abruption, placenta previa, The incidence of postpartum hemorrhage was significantly higher than that in the control group (P <0.05). The pregnant week of the female infertility group was significantly lower than that in the control group[(38.51-2.15) weeks vs. (38.97-1.85) weeks vs. (38.64-2.16) weeks, P0.05)]. The incidence of low birth weight was significantly higher in the control group (8.94% vs. 4.35%, P0.05). Conclusion In vitro fertilization-embryo transfer, the occurrence rate of single-pregnancy premature labor is increased, which may be related to the incidence of pregnancy complication of female infertility women.
【作者單位】： 北京大學(xué)第三醫(yī)院生殖醫(yī)學(xué)中心
【基金】：首都衛(wèi)生發(fā)展科研專項(xiàng)項(xiàng)目(首發(fā)2014-1-4091)
【分類號(hào)】：R714.8

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