【摘要】：目的評價左炔諾孕酮宮內緩釋給藥與米非司酮治療圍絕經期功能失調性子宮出血患者的臨床療效和安全性。方法 106例圍絕經期功能失調性子宮出血患者隨機分為試驗組和對照組,各53例,試驗組患者用左炔諾孕酮緩釋系統(tǒng)治療,對照組患者用米非司酮治療,觀察2組患者治療前后臨床療效、不良反應發(fā)生率及對患者子宮內膜厚度、月經量、血紅蛋白濃度的影響。結果試驗組有效率(94.34%)顯著高于對照組(67.92%,P0.05);試驗組患者不良反應發(fā)生率(7.55%)顯著低于對照組(33.96%,P0.05)。治療后,2組患者子宮內膜厚度、月經量顯著降低,血紅蛋白濃度顯著升高(P0.05),且試驗組治療后上述指標變化更為顯著(P0.05)。結論左炔諾孕酮宮內緩釋系統(tǒng)治療圍絕經期功能失調性子宮出血療效顯著,不良反應發(fā)生率低。
[Abstract]:Objective to evaluate the clinical efficacy and safety of levonorgestrel sustained release administration and mifepristone in the treatment of perioperative dysfunctional uterine bleeding. Methods 106 patients with peri-menopausal dysfunctional uterine bleeding were randomly divided into experimental group (n = 53) and control group (n = 53). The patients in the experimental group were treated with levonorgestrel sustained release system and the patients in the control group were treated with mifepristone. The clinical efficacy, incidence of adverse reactions and the effects on intimal thickness, menstrual volume and hemoglobin concentration were observed before and after treatment. Results the effective rate of the experimental group (94.34%) was significantly higher than that of the control group (67.92%, P 0.05), and the incidence of adverse reactions in the experimental group (7.55%) was significantly lower than that of the control group (33.96%, P 0.05). After treatment, the intimal thickness and menstrual volume of the two groups were significantly decreased, and the hemoglobin concentration was significantly increased (P 0.05), and the changes of the above indexes were more significant after treatment in the experimental group (P 0.05). Conclusion levonorgestrel sustained release system is effective in the treatment of menopausal dysfunctional uterine bleeding, and the incidence of adverse reactions is low.
【作者單位】： 寧波市婦女兒童醫(yī)院藥劑科;寧波市婦女兒童醫(yī)院婦產科;福建醫(yī)科大學教學醫(yī)院婦產科;
【基金】：省衛(wèi)生廳青年基金課題基金資助項目(2009229)
【分類號】：R711.52

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本文編號：2502147