再次體外受精-胚胎移植獲卵數(shù)的改變及其影響因素的分析
發(fā)布時間:2019-06-07 17:59
【摘要】:目的探討首次體外受精(IVF)-胚胎移植(ET)/卵母細胞內(nèi)單精子顯微注射(ICSI)失敗行再次IVF/ICSI-ET時獲卵數(shù)的變化以及相關(guān)影響因素的分析。方法回顧性分析222例在12個月內(nèi)行2次IVF/ICSI-ET周期的患者,根據(jù)基礎(chǔ)竇卵泡數(shù)(b AFC)將患者分為A組(b AFC≥9)和B組(b AFC9),分析每組前后兩周期間患者的基本情況、臨床方案、獲卵數(shù)、進入減數(shù)分裂中期II(MII期)卵子數(shù)、正常受精率、優(yōu)胚率、累積妊娠率的變化,探討影響前后周期獲卵數(shù)發(fā)生變化的相關(guān)因素。結(jié)果A組第二個IVF周期(cycle2)獲卵數(shù)、MII期卵子數(shù)、受精率、優(yōu)胚率、累積妊娠率明顯高于第一個IVF周期(cycle1),前后周期中臨床方案無大的變化,均以長方案為主,但cycle2每日的促性腺激素(Gn)使用劑量高于cycle1(P0.05)。B組中相對于cycle1,cycle2獲卵數(shù)、MII期卵子數(shù)差異無統(tǒng)計學(xué)意義,而優(yōu)胚率及累積妊娠率均提高,并且cycle2中短方案明顯多于cycle1(P0.05)。其中B組中有14例患者在cycle1中為長方案,在cycle2中轉(zhuǎn)變?yōu)槎谭桨?后者的獲卵數(shù)以及MII期卵子數(shù)均高于前者(P0.05)。結(jié)論對于卵巢功能正常的患者,結(jié)合患者cycle1中獲卵數(shù)以及Gn使用劑量,在控制卵巢過度刺激綜合征發(fā)生的情況下,cycle2中可通過適當?shù)奶岣呙咳誈n使用劑量來提高獲卵數(shù)及MII期卵子數(shù)。相對于長方案,短方案可能更適合卵巢功能減退的患者。
[Abstract]:Objective to investigate the changes of the number of eggs obtained by (ET) / intracytozoa microinjection of (ICSI) for the first time in vitro fertilisation and embryo transfer and the analysis of related influencing factors. Methods 222 patients undergoing two IVF/ICSI-ET cycles within 12 months were analyzed retrospectively. according to the number of basic sinus follicles (b AFC), the patients were divided into group A (b AFC 鈮,
本文編號:2494981
[Abstract]:Objective to investigate the changes of the number of eggs obtained by (ET) / intracytozoa microinjection of (ICSI) for the first time in vitro fertilisation and embryo transfer and the analysis of related influencing factors. Methods 222 patients undergoing two IVF/ICSI-ET cycles within 12 months were analyzed retrospectively. according to the number of basic sinus follicles (b AFC), the patients were divided into group A (b AFC 鈮,
本文編號:2494981
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