短時IVF聯(lián)合早期補(bǔ)救ICSI與half-ICSI預(yù)防初次助孕周期受精低下的比較
發(fā)布時間:2019-06-05 11:55
【摘要】:目的對比分析短時體外受精(IVF)或短時IVF聯(lián)合早期補(bǔ)救卵胞漿內(nèi)單精子顯微注射(ICSI)與部分卵胞漿內(nèi)單精子顯微注射(half-ICSI)兩種授精方式在首次助孕周期對預(yù)防IVF受精率低下的療效。方法回顧性分析2015年5月1日—2016年12月31日初次助孕周期中因存在精卵結(jié)合障礙高危因素而接受短時IVF(或短時IVF聯(lián)合聯(lián)合早期補(bǔ)救ICSI)或half-ICSI預(yù)防IVF受精率低下患者的病例資料。根據(jù)授精方式分為短時IVF助孕組(A組,n=192)和half-ICSI助孕組(B組,n=85),比較兩組患者的一般情況、受精情況、胚胎發(fā)育以及接受新鮮胚胎移植后的妊娠結(jié)局。為進(jìn)一步分析受精情況,篩選A、B兩組中IVF受精率低下周期(受精率≤30%)的患者,分別設(shè)為A1組(n=20)和B1組(n=9),比較A1、B1兩組的卵子受精情況。結(jié)果與B組相比,A組不存在過度ICSI(0.0%vs89.8%,χ~2=479.888,P0.01)。A組正常受精率低于B組(73.3%vs 79.6%,χ~2=14.780,P0.01),但兩組可用胚胎率、優(yōu)質(zhì)胚胎率、囊胚形成率以及接受新鮮胚胎移植后臨床妊娠率、胚胎著床率、流產(chǎn)率差異均無統(tǒng)計學(xué)意義(P均0.05)。IVF受精率低下周期中,短時IVF聯(lián)合早期補(bǔ)救ICSI可提高正常受精率(A1組77.9%,B1組49.4%,χ~2=28.833,P0.01)。結(jié)論相比half-ICSI,短時IVF聯(lián)合早期補(bǔ)救ICSI可避免過度ICSI、提高IVF受精率低下周期的正常受精率,預(yù)防IVF受精率低下更加精確、有效。
[Abstract]:Objective to compare short-term in vitro fertilization (IVF) or short-term IVF combined with early remediation of intracytoplasmic sperm microinjection (ICSI) and partial intracytoplasmic sperm microinjection (half-ICSI) in the first trimester of pregnancy. The effect of stage on the prevention of low fertilizing rate of IVF. Methods from May 1, 2015 to December 31, 2016, short-term IVF (or short-term IVF combined with early remedial ICSI) or half-ICSI were used to prevent IVF fertilization due to the high risk factors of sperm-egg binding disorder in the first assisted pregnancy cycle. Case data of patients with low rate. According to the mode of indoctrination, the patients were divided into short-term IVF assisted pregnancy group (group A, n 鈮,
本文編號:2493508
[Abstract]:Objective to compare short-term in vitro fertilization (IVF) or short-term IVF combined with early remediation of intracytoplasmic sperm microinjection (ICSI) and partial intracytoplasmic sperm microinjection (half-ICSI) in the first trimester of pregnancy. The effect of stage on the prevention of low fertilizing rate of IVF. Methods from May 1, 2015 to December 31, 2016, short-term IVF (or short-term IVF combined with early remedial ICSI) or half-ICSI were used to prevent IVF fertilization due to the high risk factors of sperm-egg binding disorder in the first assisted pregnancy cycle. Case data of patients with low rate. According to the mode of indoctrination, the patients were divided into short-term IVF assisted pregnancy group (group A, n 鈮,
本文編號:2493508
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