香煙煙霧誘導下的自噬對卵泡發(fā)育的影響
發(fā)布時間:2019-05-21 22:25
【摘要】:吸煙是一種不良的生活習慣,全球大約有2.5億的女性吸煙,但大多數(shù)吸煙女性并沒有意識到吸煙對卵巢功能和生育力的影響。長期接觸香煙煙霧可以減少原始卵泡和生長發(fā)育階段卵泡的數(shù)量,使卵巢卵泡儲存量下降和卵巢功能減弱,致使女性生育力下降,并提早進入更年期。香煙煙霧可以誘導自噬的發(fā)生,并且自噬是香煙煙霧誘導卵巢卵泡丟失的關(guān)鍵原因,調(diào)節(jié)自噬過程可能成為控制香煙煙霧所致卵巢早衰的潛在治療方法。
[Abstract]:Smoking is a bad habit, about 250 million of the world's women smoke, but most smoking women are not aware of the impact of smoking on ovarian function and fertility. Long-term exposure to cigarette smoke can reduce the number of primordial follicles and follicles during growth and development, decrease the storage of ovarian follicles and weaken ovarian function, resulting in the decrease of fertility of women and enter the menopausal period early. Cigarette smoke can induce autophagy, and autophagy is the key cause of ovarian follicular loss induced by cigarette smoke. Regulating autophagy process may be a potential treatment to control premature ovarian failure caused by cigarette smoke.
【作者單位】: 嘉興學院醫(yī)學院;寧波大學醫(yī)學院;
【基金】:國家級大學生創(chuàng)新創(chuàng)業(yè)訓練計劃項目(批準號:20141035019) 嘉興學院SRT項目(批準號:2015SRT)資助的課題~~
【分類號】:R711.75
本文編號:2482451
[Abstract]:Smoking is a bad habit, about 250 million of the world's women smoke, but most smoking women are not aware of the impact of smoking on ovarian function and fertility. Long-term exposure to cigarette smoke can reduce the number of primordial follicles and follicles during growth and development, decrease the storage of ovarian follicles and weaken ovarian function, resulting in the decrease of fertility of women and enter the menopausal period early. Cigarette smoke can induce autophagy, and autophagy is the key cause of ovarian follicular loss induced by cigarette smoke. Regulating autophagy process may be a potential treatment to control premature ovarian failure caused by cigarette smoke.
【作者單位】: 嘉興學院醫(yī)學院;寧波大學醫(yī)學院;
【基金】:國家級大學生創(chuàng)新創(chuàng)業(yè)訓練計劃項目(批準號:20141035019) 嘉興學院SRT項目(批準號:2015SRT)資助的課題~~
【分類號】:R711.75
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