雙循環(huán)雙通道方案對(duì)合并妊娠的重度卵巢過度刺激綜合征的治療效果
發(fā)布時(shí)間：2019-04-29 13:20
【摘要】：目的分析比較不同治療方案在合并妊娠的重度卵巢過度刺激綜合征(OHSS)中的治療效果,以探討雙循環(huán)雙通道方案對(duì)合并妊娠的重度OHSS的治療優(yōu)勢(shì)。方法收集60例經(jīng)體外受精-胚胎移植(IVF-ET)成功妊娠的重度OHSS患者作為研究對(duì)象�；仡櫺苑治銎渲委煼桨�,分為常規(guī)單循環(huán)治療組(A組),雙循環(huán)雙通道治療組(B組)。分別比較其治療前、治療后第3d、治療后第9d兩組患者的體質(zhì)量(BM)、腹圍(AC)、B超下的腹水最大深度(D)、血清白蛋白(ALB)、Na+濃度、白細(xì)胞計(jì)數(shù)(WBC)、紅細(xì)胞壓積(HCT)、尿量以及飲入量的變化;并比較兩組的住院天數(shù)、住院費(fèi)用、腹穿次數(shù)、總的白蛋白用量和妊娠結(jié)局。結(jié)果 1兩組對(duì)象在入院時(shí)各指標(biāo)差異均無(wú)統(tǒng)計(jì)學(xué)意義。2治療后第3dBM、HCT較治療前的變化值兩組間差異無(wú)統(tǒng)計(jì)學(xué)意義;治療后第9d僅HCT B組下降較A組更明顯(P0.05)。3治療后第3d,AC、WBC均較治療前降低,B組減少更明顯(P0.05),A組D變化不明顯,有部分患者甚至增加,B組則較治療前降低(P0.05);治療后第9d,AC、D、WBC均較治療前降低,B組減少更明顯(P0.05);兩組尿量、飲入量均較治療前增加,B組增加更明顯(P0.05)。4治療后第3d,ALB較治療前降低,B組下降少于A組(P0.05);治療后第9d,兩組患者ALB均較治療前升高,B組升高更明顯(P0.05)。5B組的住院時(shí)間、住院費(fèi)用均少于A組(P0.05),A組輸注白蛋白的量和腹穿次數(shù)多于B組(P0.05)。6B組患者均成功妊娠,A組有1例患者治療效果差,終止妊娠。結(jié)論采用雙循環(huán)雙通道的治療方案,能有效糾正OHSS患者的"三低一高"(低蛋白血癥、低滲透壓、低血容量及高血凝狀態(tài))的病理狀態(tài),減少患者的住院時(shí)間及費(fèi)用。
[Abstract]:Objective to analyze and compare the therapeutic effects of different treatment regimens on severe ovarian hyperstimulation syndrome (OHSS) complicated with pregnancy, and to explore the advantages of dual circulation and dual channel regimen in the treatment of severe OHSS complicated with pregnancy. Methods 60 patients with severe OHSS who were successfully pregnant by in vitro fertilization-embryo transfer (IVF-ET) were selected as subjects. The therapeutic regimen was retrospectively analyzed and divided into routine single circulation treatment group (A group) and double circulation and double channel treatment group (B group). Before treatment, 3 days after treatment, and 9 days after treatment, the maximum serum albumin (ALB), Na concentration and white blood cell count (WBC), of ascites with (BM), abdominal circumference (AC), ultrasound in the two groups were compared with those before treatment, 3 days after treatment and 9 days after treatment respectively. Changes in urine volume and intake of hematocrit (HCT),; The hospitalization days, hospital expenses, abdominal puncture times, total albumin dosage and pregnancy outcome were compared between the two groups. Results (1) there was no significant difference in each index between the two groups on admission. (2) there was no significant difference between the two groups in the changes of BM and HCT on the 3rd day after treatment compared with those before treatment. On the 9th day after treatment, the decrease of AC,WBC in HCT group B was more obvious than that in group A (P0.05). 3 on the 3rd day after treatment, AC,WBC decreased more significantly in group B than that before treatment (P 0.05), A group, D change was not obvious, and some patients even increased, P 0.05, P < 0.05). Group B was lower than that before treatment (P0.05). On the 9th day after treatment, AC,D,WBC was lower than that before treatment, and the decrease was more obvious in group B (P0.05). The urine volume and drinking volume in both groups were higher than those before treatment, and the increase in group B was more obvious than that before treatment (P0.05). 4 on the 3rd day after treatment, ALB was lower in group B than that before treatment, and the decrease in group B was less than that in group A (P0.05). On the 9th day after treatment, the ALB of both groups was higher than that of pre-treatment, and the increase of group B was more obvious (P0.05). 5the length of hospitalization and the cost of hospitalization in group B were lower than those in group A (P0.05). The amount of albumin infusion and the times of abdominal puncture in group A were higher than those in group B (P0.05). All the patients in group 6B were pregnant successfully, and one patient in group A had poor therapeutic effect to terminate pregnancy. Conclusion double circulation and double channel therapy can effectively correct the pathological status of OHSS patients (hypoproteinemia, low osmolarity, hypovolemia and hypercoagulability), and reduce the length of stay and the cost of hospitalization of the patients. [WT5 "HZ] conclusion\?
【作者單位】： 四川大學(xué)華西第二醫(yī)院生殖內(nèi)分泌科;
【分類號(hào)】：R714.8
[Abstract]:Objective to analyze and compare the therapeutic effects of different treatment regimens on severe ovarian hyperstimulation syndrome (OHSS) complicated with pregnancy, and to explore the advantages of dual circulation and dual channel regimen in the treatment of severe OHSS complicated with pregnancy. Methods 60 patients with severe OHSS who were successfully pregnant by in vitro fertilization-embryo transfer (IVF-ET) were selected as subjects. The therapeutic regimen was retrospectively analyzed and divided into routine single circulation treatment group (A group) and double circulation and double channel treatment group (B group). Before treatment, 3 days after treatment, and 9 days after treatment, the maximum serum albumin (ALB), Na concentration and white blood cell count (WBC), of ascites with (BM), abdominal circumference (AC), ultrasound in the two groups were compared with those before treatment, 3 days after treatment and 9 days after treatment respectively. Changes in urine volume and intake of hematocrit (HCT),; The hospitalization days, hospital expenses, abdominal puncture times, total albumin dosage and pregnancy outcome were compared between the two groups. Results (1) there was no significant difference in each index between the two groups on admission. (2) there was no significant difference between the two groups in the changes of BM and HCT on the 3rd day after treatment compared with those before treatment. On the 9th day after treatment, the decrease of AC,WBC in HCT group B was more obvious than that in group A (P0.05). 3 on the 3rd day after treatment, AC,WBC decreased more significantly in group B than that before treatment (P 0.05), A group, D change was not obvious, and some patients even increased, P 0.05, P < 0.05). Group B was lower than that before treatment (P0.05). On the 9th day after treatment, AC,D,WBC was lower than that before treatment, and the decrease was more obvious in group B (P0.05). The urine volume and drinking volume in both groups were higher than those before treatment, and the increase in group B was more obvious than that before treatment (P0.05). 4 on the 3rd day after treatment, ALB was lower in group B than that before treatment, and the decrease in group B was less than that in group A (P0.05). On the 9th day after treatment, the ALB of both groups was higher than that of pre-treatment, and the increase of group B was more obvious (P0.05). 5the length of hospitalization and the cost of hospitalization in group B were lower than those in group A (P0.05). The amount of albumin infusion and the times of abdominal puncture in group A were higher than those in group B (P0.05). All the patients in group 6B were pregnant successfully, and one patient in group A had poor therapeutic effect to terminate pregnancy. Conclusion double circulation and double channel therapy can effectively correct the pathological status of OHSS patients (hypoproteinemia, low osmolarity, hypovolemia and hypercoagulability), and reduce the length of stay and the cost of hospitalization of the patients. [WT5 "HZ] conclusion\?
【作者單位】： 四川大學(xué)華西第二醫(yī)院生殖內(nèi)分泌科;
【分類號(hào)】：R714.8
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