【摘要】：目的應(yīng)用Meta分析探討宮頸癌的相關(guān)易感基因人白細(xì)胞抗原-DRB1基因的不同位點(diǎn)多態(tài)性與宮頸癌發(fā)病風(fēng)險(xiǎn)的關(guān)系。 方法通過(guò)檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)(CNKI)、維普科技期刊數(shù)據(jù)庫(kù)(VIP)、萬(wàn)方數(shù)據(jù)、PubMed.Elsevier.Springer Link和口Cochrane Library database數(shù)據(jù)庫(kù),應(yīng)用關(guān)鍵詞或主題詞“宮頸癌”、“等位基因”、“基因多態(tài)性”、“人類(lèi)白細(xì)胞抗原”、‘'HLA-DRB"搜索從各數(shù)據(jù)庫(kù)建庫(kù)起到2013年5月份發(fā)表的有關(guān)人類(lèi)白細(xì)胞抗原基因(HLA-DRB1)基因多態(tài)性與宮頸癌易感性關(guān)系的病例對(duì)照研究的中英文文獻(xiàn),全面檢索相關(guān)文獻(xiàn)并剔除不符合要求的文獻(xiàn),最終納入12篇。利用RevMan5.0對(duì)各研究結(jié)果進(jìn)行異質(zhì)性檢驗(yàn)和效應(yīng)值合并計(jì)算,選擇OR值及其95%CI作為Meta分析指標(biāo)。若各獨(dú)立研究結(jié)果具有同質(zhì)性,采用固定效應(yīng)模型(F),反之則采用隨機(jī)模型(R),用Stata10.0軟件的Begg's檢驗(yàn)和Egger's檢驗(yàn)分析發(fā)表偏倚。 結(jié)果實(shí)驗(yàn)組與對(duì)照組相比,等位基因HLA-DRB1*03、HLA-DRB1*08和HLA-DRB1*12是中國(guó)人群宮頸癌的保護(hù)基因(均P0.05),等位基因HLA-DRB1*10. HLA-DRB1*14.HLA-DRBl*15.HLA-DRBl*0301.HLA-DRB1*0403.HLA-DRB1*0404. HLA-DRB1*0803.HLA-DRB1*1312和HLA-DRB1*1502是中國(guó)人群宮頸癌的危險(xiǎn)基因(均P0.05)。 結(jié)論本Meta分析結(jié)果表明,HLA-DRB1基因多態(tài)性與中國(guó)人群宮頸癌的易感性存在一定的關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between the polymorphism of human leukocyte antigen-DRB1 gene and the risk of cervical cancer by Meta analysis. Methods by searching the full-text database of Chinese academic journals, (VIP), Wanfang data, PubMed.Elsevier.Springer Link database and oral Cochrane Library database, using the keywords or subject words "cervical cancer" and "alleles", (CNKI), Wafang data, PubMed.Elsevier.Springer Link database and oral Cochrane Library database were used. "genetic polymorphism", "human leukocyte antigen", The 'HLA-DRB' search for Chinese and English literature on the relationship between human leukocyte antigen (HLA-DRB1) gene polymorphism and susceptibility to cervical cancer published in May 2013 from the establishment of databases to the publication of a case-control study on the association of human leukocyte antigen (HLA-DRB1) gene polymorphisms with susceptibility to cervical cancer Comprehensive retrieval of relevant literature and elimination of non-compliant literature, finally included in 12. RevMan5.0 was used to test the heterogeneity of the research results and to combine the effect values. The OR value and its 95%CI were selected as the index of Meta analysis. If the independent research results are homogeneous, the fixed effect model (F), is used instead, the random model (R), is used to analyze the bias of publication with Stata10.0 software Begg's test and Egger's test. Results compared with the control group, the allele HLA-DRB1*03,HLA-DRB1*08 and HLA-DRB1*12 were the protective genes of cervical cancer in Chinese population (P0.05), and the allele HLA-DRB1*10. was the same as that of the control group. HLA-DRB1*14.HLA-DRBl*15.HLA-DRBl*0301.HLA-DRB1*0403.HLA-DRB1*0404. HLA-DRB1*0803.HLA-DRB1*1312 and HLA-DRB1*1502 were risk genes for cervical cancer in Chinese population (P0.05). Conclusion the results of Meta analysis showed that the polymorphism of HLA-DRB1 gene was associated with the susceptibility to cervical cancer in Chinese population.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R737.33

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