【摘要】：目的：探討轉錄因子Snail和緊密連接蛋白Claudin3在子宮腺肌病的異位和在位內(nèi)膜中的表達及意義。 方法：采用免疫組化法檢測40例子宮腺肌病的異位內(nèi)膜、在位內(nèi)膜和10例正常子宮內(nèi)膜中Snail及Claudin3的表達。 結果：1、Snail在腺肌病的異位內(nèi)膜、在位內(nèi)膜及正常子宮內(nèi)膜中陽性表達率分別90.0%、62.5%和50.0%,各組比較均具有顯著性差異(P0.05)；在位內(nèi)膜及正常子宮內(nèi)膜中分泌期與增生期的陽性表達率均無顯著性差異(P0.05)。 2、Claudin3在腺肌病的異位內(nèi)膜、在位內(nèi)膜及正常子宮內(nèi)膜的陽性表達率分別57.5%、85.0%、90.0%,各組比較均具有顯著性差異(P0.05)；在位內(nèi)膜及正常子宮內(nèi)膜中分泌期與增生期的陽性表達率均無顯著性差異(P0.05)。 3、Snail與Claudin3在子宮腺肌病的異位內(nèi)膜中的表達呈負相關(P0.05)。 結論：Snail在子宮腺肌病中表達上調(diào),而Claudin3在表達下調(diào),提示異常子宮內(nèi)膜細胞更易遷移至肌層組織,兩者表達的負相關性與內(nèi)膜浸潤性生長的生物學特性相關；Snail及Claudin3可能共同參與上皮-間質轉化作用并促進子宮腺肌病的發(fā)生。
[Abstract]:Aim: to investigate the expression and significance of transcription factor Snail and tight junction protein Claudin3 in ectopic and eutopic endometrium of adenomyosis. Methods: immunohistochemical method was used to detect the expression of Snail and Claudin3 in ectopic endometrium, eutopic endometrium and 10 normal endometrium of 40 cases of adenomyosis. Results: 1 the positive expression rate of Snail in ectopic endometrium, eutopic endometrium and normal endometrium of adenomyosis was 90.0%, 62.5% and 50.0%, respectively (P0.05). There was no significant difference in the positive expression rate between secretory phase and proliferative phase in ectopic endometrium and normal endometrium (P0.05). 2. The positive expression rate of Claudin 3 in ectopic endometrium, eutopic endometrium and normal endometrium of adenomyosis was 57.5%, 85.0% and 90.0%, respectively (P0.05). There was no significant difference in the positive expression rate between secretory phase and proliferative phase in ectopic endometrium and normal endometrium (P0.05). 3. There was a negative correlation between the expression of Snail and Claudin3 in ectopic endometrium of adenomyosis (P0.05). Conclusion: the expression of Snail is up-regulated in adenomyosis, while the expression of Claudin3 is down-regulated, suggesting that abnormal endometrial cells are more likely to migrate to myometrium, and the negative correlation between the two expressions is related to the biological characteristics of invasive growth of endometrium. Snail and Claudin3 may be involved in epithelial-interstitial transformation and promote adenomyosis.
【學位授予單位】：延邊大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R711.71

【參考文獻】

相關期刊論文 前6條

1 魏佑榮;;高強度聚焦超聲治療子宮肌瘤及子宮腺肌病臨床研究[J];濱州醫(yī)學院學報;2010年05期

2 彭超;周應芳;;子宮腺肌病病因的基礎研究進展[J];婦產(chǎn)與遺傳(電子版);2012年01期

3 張莉麗;張布衣;姚根有;;組織芯片檢測snail mRNA的表達及其與胃癌的關系[J];浙江臨床醫(yī)學;2008年08期

4 鄭振m(;張布衣;姚根有;;通過組織芯片分析snail、claudin-1 mRNA表達與胃癌的關系[J];醫(yī)學研究雜志;2006年12期

5 洪穎,胡婭莉,呂翔,張葵,周祀喬,惲時鋒;氨甲喋呤與米非司酮局部應用治療鼠子宮內(nèi)膜異位癥研究[J];中國實用婦科與產(chǎn)科雜志;2000年12期

6 韓燕華,周應芳,鄭淑蓉;子宮腺肌病患者血管內(nèi)皮生長因子表達的研究[J];中華婦產(chǎn)科雜志;2002年09期

，

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