【摘要】：目的:探討人類凍融胚胎質(zhì)量對(duì)早期臨床妊娠結(jié)局的影響。方法:回顧性分析了2012年3月至2015年6月期間,在我院生殖中心進(jìn)行玻璃化冷凍的人類凍融胚胎移植(Frozen-thawed Embryos Transfer,FET)的738個(gè)周期的患者的相關(guān)資料,分別按照移植優(yōu)質(zhì)胚胎的數(shù)量、卵裂球損傷的程度、移植胚胎中是否含8細(xì)胞胚胎以及含8細(xì)胞胚胎的數(shù)目,將其分為4類組,分別比較各分類組間的早期臨床妊娠率和多胎妊娠率之間的差異。結(jié)果:(1)移植2枚優(yōu)質(zhì)胚胎組早期臨床妊娠率均高于移植0枚優(yōu)質(zhì)胚胎組和移植1枚優(yōu)質(zhì)胚胎組(P0.05),并且與移植3枚優(yōu)質(zhì)胚胎組是早期臨床妊娠率基本相同;各組間的多胎妊娠率無(wú)統(tǒng)計(jì)學(xué)差異;(2)移植胚胎完整組、損傷組、損傷混合組各組間的早期臨床妊娠率、多胎妊娠率均無(wú)統(tǒng)計(jì)學(xué)差異;(3)移植8細(xì)胞胚胎組的早期臨床妊娠率顯著高于移植6-7或9-13細(xì)胞胚胎組(P0.05),且各組間的多胎妊娠率無(wú)統(tǒng)計(jì)學(xué)差異。(4)移植2枚8細(xì)胞胚胎組的種植率、早期臨床妊娠率顯著高于移植0枚8細(xì)胞胚胎組和移植1枚8細(xì)胞胚胎組(P0.05);移植3枚8細(xì)胞胚胎組的多胎妊娠率顯著高于移植0枚8細(xì)胞胚胎組(P0.05),其余組間差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論：FET中移植的優(yōu)質(zhì)胚胎數(shù)目和8細(xì)胞胚胎數(shù)目是影響早期臨床妊娠率和多胎妊娠率的重要因素;胚胎損傷對(duì)早期臨床妊娠率和多胎妊娠率無(wú)明顯影響。因此,FET時(shí)移植至少1枚優(yōu)質(zhì)胚胎或1枚8細(xì)胞胚胎,既可以保證其早期臨床妊娠率,同時(shí)又可以降低多胎妊娠率。
[Abstract]:Objective: to investigate the effect of human frozen-thawed embryo quality on the outcome of early pregnancy. Methods: the data of 738 cycles of vitrification frozen human frozen embryo transfer (Frozen-thawed Embryos Transfer,FET) from March 2012 to June 2015 in our hospital were retrospectively analyzed. They were divided into four groups according to the number of high-quality embryos transferred, the degree of blastomere injury, and whether the transferred embryos contained 8-cell embryos and the number of 8-cell embryos. The differences of early clinical pregnancy rate and multiple pregnancy rate among different groups were compared. Results: (1) the early pregnancy rate of the two high-quality embryos group was higher than that of 0 high-quality embryo group and 1 high-quality embryo group (P0.05), and the rate of early clinical pregnancy was basically the same as that of the three high-quality embryo group. (2) there was no significant difference in early clinical pregnancy rate and multiple pregnancy rate among the groups of intact embryo transfer group, injury-mixed group and multiple pregnancy group; (2) there was no significant difference in early clinical pregnancy rate and multiple pregnancy rate among the groups of intact embryo transfer group and injury mixed group. (3) the rate of early clinical pregnancy in 8-cell embryo transplantation group was significantly higher than that in 6 / 7 or 9 / 13 cell embryo transplantation group (P0.05). (4) the early clinical pregnancy rate of 2 8-cell embryos transplanted group was significantly higher than that of 0 8-cell embryo transplantation group and 1 8-cell embryo transplantation group (P0.05). The multiple pregnancy rate of 3 8-cell embryos transplanted group was significantly higher than that of 0 8-cell embryo transplantation group (P0.05), but there was no significant difference among the other groups. Conclusion: the number of high-quality embryos and the number of 8-cell embryos transferred in FET are important factors affecting early clinical pregnancy rate and multiple pregnancy rate, but embryo injury has no significant effect on early clinical pregnancy rate and multiple pregnancy rate. Therefore, the transfer of at least one high-quality embryo or one 8-cell embryo during FET can not only guarantee the early clinical pregnancy rate, but also reduce the multiple pregnancy rate.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R714.8

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