【摘要】：目的系統(tǒng)評價甲基多巴和拉貝洛爾治療妊娠期高血壓疾病的有效性及安全性。方法檢索Med Line,Cochrane Library,EMbase,中國知網、萬方、維普等數(shù)據(jù)庫中公開發(fā)表的甲基多巴和拉貝洛爾治療妊娠期高血壓疾病的隨機對照研究,試驗組予以甲基多巴治療,對照組予以拉貝洛爾治療。用Rev Man 5.3軟件進行Meta分析。結果共納入10項隨機對照研究,共計1285例患者。試驗組和對照組的重度高血壓發(fā)生率分別為6.62%和12.21%,蛋白尿發(fā)生率分別為15.57%和8.52%,藥物不良反應發(fā)生率分別為21.82%和25.63%,胎兒/嬰兒死亡率分別為4.19%和2.84%,差異均無統(tǒng)計學意義(均P0.05)。試驗組的漿黏度明顯低于對照組,差異有統(tǒng)計學意義(RR=0.77,95%CI=0.64~0.90,P0.001)。結論甲基多巴和拉貝洛爾治療妊娠期高血壓疾病降壓療效和安全性相當,但甲基多巴在改善血漿黏度上明顯優(yōu)于拉貝洛爾。
[Abstract]:Objective to evaluate the efficacy and safety of methyldopa and Rabelolol in the treatment of hypertensive disorder complicating pregnancy. Methods A randomized controlled study of methyldopa and labelolol published in the databases of Med Line,Cochrane Library,EMbase, Wanfang, Vip and other databases was conducted in the treatment of hypertensive disorder complicating pregnancy (hypertensive disorder complicating pregnancy), and the trial group was treated with methyldopa. The control group was treated with Labelolol. Meta analysis was carried out with Rev Man 5.3 software. Results A total of 1285 patients were enrolled in 10 randomized controlled studies. The incidence of severe hypertension, proteinuria and adverse drug reactions were 6.62% and 12.21%, 15.57% and 8.52%, 21.82% and 25.63%, respectively. The fetal / infant mortality rates were 4.19% and 2.84%, respectively, and there was no significant difference (P0.05). The viscosity of the test group was significantly lower than that of the control group, the difference was statistically significant (RR=0.77,95%CI=0.64~0.90,P0.001). Conclusion the efficacy and safety of methyldopa and Labelolol in the treatment of hypertensive disorder complicating pregnancy are similar, but methyldopa is superior to Labelolol in improving plasma viscosity.
【作者單位】： 北京大學人民醫(yī)院藥劑科;
【基金】：國家自然科學基金資助項目(81503050)
【分類號】：R714.246

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