【摘要】：目的探討女性年齡對(duì)胚胎植入前遺傳學(xué)診斷及篩查(PGD/PGS)結(jié)局的影響。方法回顧性分析2015年1月1日至12月31日開展PGD/PGS治療周期的149例患者,按女性年齡將患者分為3組:Ⅰ組10例(25歲)共36枚囊胚;Ⅱ組94例(25~34歲)共329枚囊胚;Ⅲ組45例(≥35歲)共89枚囊胚。比較各組之間的胚胎正常率和臨床妊娠率。結(jié)果Ⅰ組、Ⅱ組、Ⅲ組的胚胎正常率分別為50.00%、50.15%、29.21%。Ⅰ組與Ⅲ組的胚胎正常率比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=4.855,P0.05),Ⅱ組與Ⅲ組的胚胎正常率比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=12.376,P0.05)。Ⅰ組、Ⅱ組、Ⅲ組的臨床妊娠率分別為83.33%、82.50%、40.00%。Ⅰ組與Ⅲ組的臨床妊娠率比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=3.893,P0.05),Ⅱ組與Ⅲ組的臨床妊娠率比較差異有統(tǒng)計(jì)學(xué)意義(χ~2=7.510,P0.05)。結(jié)論女性年齡對(duì)PGD/PGS結(jié)局有影響,當(dāng)女性年齡≥35歲時(shí)會(huì)明顯降低胚胎的正常率和臨床妊娠率。
[Abstract]:Objective to investigate the effect of female age on the outcome of preimplantation genetic diagnosis and screening (PGD/PGS). Methods A retrospective analysis was made on 149 patients with PGD/PGS treatment cycle from January 1 to December 31, 2015. The patients were divided into 3 groups according to female age: group 鈪，

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