IVF-ET治療后發(fā)生與未發(fā)生OHSS的PCOS患者相關(guān)指標(biāo)及結(jié)局分析
發(fā)布時(shí)間：2019-01-29 21:30
【摘要】：目的：比較體外受精胚胎移植(IVF-ET)治療后發(fā)生卵巢過度刺激綜合征(OHSS)的多囊卵巢綜合征(PCOS)患者與未發(fā)生OHSS的PCOS患者其相關(guān)指標(biāo)及結(jié)局是否有差異。方法：回顧性分析2012年1月～2013年1月因不孕癥就診于我院生殖中心的87名PCOS患者,并將其分為兩組,41名發(fā)生OHSS的PCOS患者定義為組A,46名未發(fā)生OHSS的PCOS患者定義為非OHSS組B。比較兩組在接受超促排卵(COH)治療前后相關(guān)指標(biāo)及治療結(jié)局。結(jié)果：組A的年齡、BMI、Gn總量、Gn天數(shù)均小于組B,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；組A的LH/FSH、雙側(cè)卵巢基礎(chǔ)竇卵泡數(shù)目、hCG日雙側(cè)卵巢大于14mm卵泡數(shù)目、hCG日雙側(cè)卵巢小于14mm卵泡數(shù)目、獲卵數(shù)自均大于組B,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；兩組成熟卵母細(xì)胞率(%)、正常受精胚胎率(%)、優(yōu)質(zhì)胚胎率(%)、正常卵裂胚胎率(%)、首次FET宮內(nèi)妊娠率均未見明顯差異(P0.05)；組B新鮮胚胎移植與解凍胚胎移植宮內(nèi)妊娠率未見明顯差異(P0.05)。結(jié)論：年齡越小、體型越瘦、LH/FSH越大、雙側(cè)卵巢基礎(chǔ)竇卵泡數(shù)越多的PCOS患者更容易在COH治療后發(fā)生OHSS,雖然獲卵數(shù)目更多,但其卵細(xì)胞及胚胎質(zhì)量卻未因此更高。PCOS患者無論發(fā)生OHSS與否,均不影響其首次解凍周期的宮內(nèi)妊娠率。而未發(fā)生OHSS的PCOS患者其新鮮胚胎移植與解凍胚胎移植宮內(nèi)妊娠率無顯著差別。
[Abstract]:Aim: to compare the correlation indexes and outcomes of polycystic ovary syndrome (PCOS) with ovarian hyperstimulation syndrome (OHSS) after in vitro fertilization and embryo transfer (IVF-ET) between patients with polycystic ovary syndrome (PCOS) and those without OHSS (PCOS). Methods: from January 2012 to January 2013, 87 PCOS patients with infertility were analyzed and divided into two groups. 41 PCOS patients with OHSS were defined as group A. 46 PCOS patients without OHSS were defined as B in non OHSS group. The relative indexes and outcome were compared between the two groups before and after the treatment with hyperstimulation of ovulation (COH). Results: the age, total BMI,Gn and Gn days of group A were lower than that of group B (P0.05). In group A, the number of basal antral follicles in both ovaries of LH/FSH, the number of follicles in bilateral ovaries on hCG day was larger than that of 14mm follicles, and the number of ovarian follicles in both sides of ovary on hCG day was smaller than that of 14mm follicles, and the number of obtained eggs in group A was higher than that in group B (P0.05). The rate of matured oocytes (%), normal fertilization embryos (%), high quality embryos (%), normal cleavage embryos (%) and intrauterine pregnancy rate of first FET were not significantly different between the two groups (P0.05). There was no significant difference in intrauterine pregnancy rate between group B fresh embryo transfer and thawed embryo transfer (P0.05). Conclusion: the younger the age, the thinner the body, the larger the LH/FSH, the more the number of basic antral follicles in the bilateral ovaries is, the more OHSS, will occur in the patients with PCOS after COH treatment. However, the quality of eggs and embryos was not higher. No matter whether OHSS occurred or not, the rate of intrauterine pregnancy in PCOS patients was not affected by the first thawing cycle. However, there was no significant difference in intrauterine pregnancy rate between fresh embryo transfer and thawed embryo transfer in PCOS patients without OHSS.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R711.75;R714.8
本文編號(hào)：2417881
[Abstract]:Aim: to compare the correlation indexes and outcomes of polycystic ovary syndrome (PCOS) with ovarian hyperstimulation syndrome (OHSS) after in vitro fertilization and embryo transfer (IVF-ET) between patients with polycystic ovary syndrome (PCOS) and those without OHSS (PCOS). Methods: from January 2012 to January 2013, 87 PCOS patients with infertility were analyzed and divided into two groups. 41 PCOS patients with OHSS were defined as group A. 46 PCOS patients without OHSS were defined as B in non OHSS group. The relative indexes and outcome were compared between the two groups before and after the treatment with hyperstimulation of ovulation (COH). Results: the age, total BMI,Gn and Gn days of group A were lower than that of group B (P0.05). In group A, the number of basal antral follicles in both ovaries of LH/FSH, the number of follicles in bilateral ovaries on hCG day was larger than that of 14mm follicles, and the number of ovarian follicles in both sides of ovary on hCG day was smaller than that of 14mm follicles, and the number of obtained eggs in group A was higher than that in group B (P0.05). The rate of matured oocytes (%), normal fertilization embryos (%), high quality embryos (%), normal cleavage embryos (%) and intrauterine pregnancy rate of first FET were not significantly different between the two groups (P0.05). There was no significant difference in intrauterine pregnancy rate between group B fresh embryo transfer and thawed embryo transfer (P0.05). Conclusion: the younger the age, the thinner the body, the larger the LH/FSH, the more the number of basic antral follicles in the bilateral ovaries is, the more OHSS, will occur in the patients with PCOS after COH treatment. However, the quality of eggs and embryos was not higher. No matter whether OHSS occurred or not, the rate of intrauterine pregnancy in PCOS patients was not affected by the first thawing cycle. However, there was no significant difference in intrauterine pregnancy rate between fresh embryo transfer and thawed embryo transfer in PCOS patients without OHSS.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R711.75;R714.8
【共引文獻(xiàn)】
相關(guān)期刊論文 前2條
1 王培;凌秀鳳;李秀玲;盧瑩;蘇雁;張娟;趙純;;促性腺激素釋放激素拮抗劑在防治卵巢過度刺激綜合征中的應(yīng)用[J];中華臨床醫(yī)師雜志(電子版);2013年19期
2 葛明曉;陶莉莉;鄧偉民;;卵巢過度刺激綜合征的中西醫(yī)診療研究進(jìn)展[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2014年14期
相關(guān)碩士學(xué)位論文 前1條
1 喬明靜;卵巢過度刺激征高�；颊啧r胚移植與凍胚移植臨床結(jié)局分析[D];華中科技大學(xué);2013年
，本文編號(hào)：2417881
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