【摘要】：目的探討促性腺激素釋放激素(GnRH-a)與媽富隆聯(lián)合應(yīng)用治療子宮內(nèi)膜異位癥(EM)的療效。方法選擇EM患者100例,分為對照組48例、觀察組52例。對照組予GnRH-a類藥物醋酸曲普瑞林3.6 mg經(jīng)腹部皮下注射,每隔28 d注射1次,共6次。觀察組采用醋酸曲普瑞林皮下注射聯(lián)合媽富隆口服治療。治療3個(gè)月時(shí)評價(jià)臨床療效,采用女性性功能指數(shù)FSFI問卷調(diào)查表評價(jià)治療前后腹部疼痛癥狀評分,采用陰道B超檢測子宮內(nèi)膜厚度,采用電化學(xué)發(fā)光全自動(dòng)免疫分析儀檢測血清炎癥因子IL-18、TNF-α及性激素卵泡刺激素(FSH)、雌二醇(E2)水平。結(jié)果觀察組、對照組有效率分別為96.15%(50/52)、83.33%(40/48),觀察組有效率高于對照組(P0.05)。觀察組治療后盆腔痛、痛經(jīng)、性交痛和疼痛總分均低于對照組(P均0.05)。觀察組治療后子宮內(nèi)膜厚度低于對照組(P0.05)。觀察組治療后血清IL-18、TNF-α、FSH、E2水平均低于對照組(P均0.05)。結(jié)論GnRH-a聯(lián)合媽富隆對EM患者有較好的治療效果,可明顯改善患者的臨床癥狀、炎癥程度及激素水平。
[Abstract]:Objective to evaluate the efficacy of gonadotropin releasing hormone (GnRH-a) combined with mafulon in the treatment of endometriosis with (EM). Methods 100 patients with EM were divided into control group (n = 48) and observation group (n = 52). The control group was treated with triplatin acetate 3.6 mg subcutaneously by abdominal injection every 28 days for 6 times. The observation group was treated with triplatin acetate subcutaneously combined with oral administration of Maflon. After 3 months of treatment, the clinical efficacy was evaluated, the abdominal pain symptom score was evaluated by FSFI questionnaire before and after treatment, and the endometrial thickness was measured by vaginal ultrasound. The levels of serum inflammatory factor IL-18,TNF- 偽 and sex hormone follicle stimulating hormone (FSH), estradiol (E 2) were measured by electrochemiluminescence automatic immunoassay. Results the effective rates of the observation group and the control group were 96.15% (50 / 52) and 83.33% (40 / 48), respectively. The effective rate of the observation group was higher than that of the control group (P0.05). The total scores of pelvic pain, dysmenorrhea, dysmenorrhea and pain in the observation group were lower than those in the control group (P 0.05). The endometrial thickness in the observation group was lower than that in the control group (P0.05). The levels of serum IL-18,TNF- 偽 and FSH,E2 in the observation group were lower than those in the control group. Conclusion GnRH-a combined with Mafulong has a better therapeutic effect on EM patients, and can improve the clinical symptoms, inflammation degree and hormone level of the patients.
【作者單位】： 青海省人民醫(yī)院;
【分類號】：R711.71

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