【摘要】：目的探討人γ干擾素誘導(dǎo)蛋白16(IFI16)在子癇前期患者血清中的水平及其與子癇前期發(fā)病的相關(guān)性。方法選取2015年8月到2016年3月在鄭州大學(xué)第三附屬醫(yī)院就診的子癇前期孕婦45例為子癇前期組,同期進(jìn)行常規(guī)孕期檢查的30例健康孕婦為對照組。采用全自動生化分析儀檢測血清中尿素氮、尿酸、肌酐等生化指標(biāo);采用ELISA方法檢測血清中IFI16和內(nèi)皮素-1(ET-1)的水平,并對血清IFI16水平與各檢測指標(biāo)之間的相關(guān)性進(jìn)行分析;受試者工作特征(ROC)曲線用于評判血清IFI16水平在預(yù)測子癇前期疾病中的價(jià)值。結(jié)果 IFI16和ET-1在子癇前期組孕婦血清中的水平明顯高于對照組(P0.01);重度子癇前期孕婦血清IFI16水平高于輕度子癇前期孕婦(P0.01)。子癇前期孕婦血清中IFI16水平與收縮壓、舒張壓、24h尿蛋白定量和血清ET-1水平呈明顯正相關(guān),與血清清蛋白水平呈負(fù)相關(guān)。以血清IFI16水平為14.47ng/mL和17.09ng/mL作為預(yù)測子癇前期及鑒別輕度子癇前期和重度子癇前期的臨界值時(shí)具有較高的靈敏度和特異性。結(jié)論孕婦血清中高水平的IFI16與子癇前期的發(fā)病具有一定相關(guān)性,并有可能成為預(yù)測子癇前期發(fā)生的新的生物學(xué)指標(biāo)。
[Abstract]:Objective to investigate the level of human interferon-緯 inducible protein 16 (IFI16) in serum of preeclampsia patients and its correlation with preeclampsia. Methods from August 2015 to March 2016, 45 preeclampsia pregnant women in the third affiliated Hospital of Zhengzhou University were selected as preeclampsia group and 30 normal pregnant women as control group. Serum urea nitrogen, uric acid and creatinine were detected by automatic biochemical analyzer. The levels of IFI16 and ET-1 in serum were detected by ELISA method, and the correlation between serum IFI16 level and each index was analyzed. The operating characteristic (ROC) curve was used to evaluate the value of serum IFI16 level in predicting preeclampsia. Results the serum levels of IFI16 and ET-1 in the preeclampsia group were significantly higher than those in the control group (P0.01), and the serum IFI16 levels in the severe preeclampsia group were higher than those in the mild preeclampsia group (P0.01). The serum levels of IFI16 in preeclampsia were positively correlated with systolic blood pressure, diastolic blood pressure, 24-hour urinary protein and serum ET-1 levels, and negatively correlated with serum albumin levels. Using serum IFI16 levels as 14.47ng/mL and 17.09ng/mL as critical values for predicting preeclampsia and differentiating mild and severe preeclampsia has high sensitivity and specificity. Conclusion the high level of IFI16 in maternal serum may be a new biological index to predict the occurrence of preeclampsia.
【作者單位】： 鄭州大學(xué)第三附屬醫(yī)院檢驗(yàn)科;商丘醫(yī)學(xué)高等�？茖W(xué)校;
【分類號】：R714.244

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