【摘要】：蛻膜自然殺傷(d NK)細(xì)胞是妊娠時(shí)聚集在母胎界面的蛻膜組織中的NK細(xì)胞,是妊娠早期蛻膜組織主要的淋巴細(xì)胞。該群NK細(xì)胞具有促進(jìn)滋養(yǎng)層細(xì)胞侵襲、促血管生成以及促進(jìn)免疫耐受等功能;而它們的功能異常直接影響妊娠的發(fā)展,是導(dǎo)致復(fù)發(fā)性流產(chǎn)發(fā)生的原因之一。對(duì)蛻膜NK細(xì)胞功能和其上游或下游調(diào)控分子的研究將為復(fù)發(fā)性流產(chǎn)治療提供新的思路。本文總結(jié)了蛻膜NK細(xì)胞的特征、功能、對(duì)妊娠的影響以及與復(fù)發(fā)性流產(chǎn)的關(guān)系。
[Abstract]:Decidua natural killer (d NK) cells are NK cells in decidua tissue gathered at the maternal and fetal interface during pregnancy, and are the main lymphocytes in decidua tissue in early pregnancy. The NK cells have the functions of promoting trophoblastic cell invasion, angiogenesis and immune tolerance, and their abnormal function directly affects the development of pregnancy, which is one of the causes of recurrent abortion. The study of decidual NK cell function and its upstream or downstream regulatory molecules will provide new ideas for the treatment of recurrent abortion. This paper summarizes the characteristics, functions, effects of decidual NK cells on pregnancy and its relationship with recurrent abortion.
【作者單位】： 第四軍醫(yī)大學(xué)唐都醫(yī)院婦產(chǎn)科;第四軍醫(yī)大學(xué)基礎(chǔ)部免疫學(xué)教研室;
【基金】：國(guó)家自然科學(xué)基金(81370710)
【分類號(hào)】：R714.21

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