蛻膜NK細胞與不明原因復發(fā)性流產(chǎn)關系的研究進展
發(fā)布時間:2018-12-12 00:56
【摘要】:蛻膜自然殺傷(d NK)細胞是妊娠時聚集在母胎界面的蛻膜組織中的NK細胞,是妊娠早期蛻膜組織主要的淋巴細胞。該群NK細胞具有促進滋養(yǎng)層細胞侵襲、促血管生成以及促進免疫耐受等功能;而它們的功能異常直接影響妊娠的發(fā)展,是導致復發(fā)性流產(chǎn)發(fā)生的原因之一。對蛻膜NK細胞功能和其上游或下游調(diào)控分子的研究將為復發(fā)性流產(chǎn)治療提供新的思路。本文總結(jié)了蛻膜NK細胞的特征、功能、對妊娠的影響以及與復發(fā)性流產(chǎn)的關系。
[Abstract]:Decidua natural killer (d NK) cells are NK cells in decidua tissue gathered at the maternal and fetal interface during pregnancy, and are the main lymphocytes in decidua tissue in early pregnancy. The NK cells have the functions of promoting trophoblastic cell invasion, angiogenesis and immune tolerance, and their abnormal function directly affects the development of pregnancy, which is one of the causes of recurrent abortion. The study of decidual NK cell function and its upstream or downstream regulatory molecules will provide new ideas for the treatment of recurrent abortion. This paper summarizes the characteristics, functions, effects of decidual NK cells on pregnancy and its relationship with recurrent abortion.
【作者單位】: 第四軍醫(yī)大學唐都醫(yī)院婦產(chǎn)科;第四軍醫(yī)大學基礎部免疫學教研室;
【基金】:國家自然科學基金(81370710)
【分類號】:R714.21
[Abstract]:Decidua natural killer (d NK) cells are NK cells in decidua tissue gathered at the maternal and fetal interface during pregnancy, and are the main lymphocytes in decidua tissue in early pregnancy. The NK cells have the functions of promoting trophoblastic cell invasion, angiogenesis and immune tolerance, and their abnormal function directly affects the development of pregnancy, which is one of the causes of recurrent abortion. The study of decidual NK cell function and its upstream or downstream regulatory molecules will provide new ideas for the treatment of recurrent abortion. This paper summarizes the characteristics, functions, effects of decidual NK cells on pregnancy and its relationship with recurrent abortion.
【作者單位】: 第四軍醫(yī)大學唐都醫(yī)院婦產(chǎn)科;第四軍醫(yī)大學基礎部免疫學教研室;
【基金】:國家自然科學基金(81370710)
【分類號】:R714.21
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1 朱亮亮;朱付凡;;早期復發(fā)性流產(chǎn)的系統(tǒng)論思考[J];醫(yī)學與哲學(臨床決策論壇版);2007年10期
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