【摘要】：目的:周圍神經(jīng)侵犯(perineural invasion,PNI)對(duì)宮頸癌病人預(yù)后的影響,目前沒有一致的結(jié)論。本研究為探討宮頸癌周圍神經(jīng)侵犯對(duì)預(yù)后的影響及其在維吾爾族和漢族間的差異。方法:回顧性分析2009-2014年413例(IB—IIB期)宮頸癌根治術(shù)后患者的臨床病理資料。其中維吾爾族患者198例,漢族患者215例。研究宮頸癌神經(jīng)侵犯與其它臨床病理特征的關(guān)系及其對(duì)宮頸癌預(yù)后的意義。結(jié)果:宮頸癌神經(jīng)侵犯的患者共有8.0%(33/413)例,其與淋巴結(jié)轉(zhuǎn)移、腫塊≥4cm、宮旁侵犯以及脈管癌栓均顯著相關(guān)(P0.05)。PNI陽性組的5年無復(fù)發(fā)生存率為76.7%,明顯低于陰性組84.6%,且差異顯著(P=0.048)。PNI陽性組與陰性組的5年生存率分別為70.6%和79.9%,但無顯著性差異(P=0.383)。針對(duì)不同民族患者進(jìn)行亞組分析的結(jié)果顯示:維吾爾族患者中PNI陽性亞組的5年無復(fù)發(fā)生存率明顯低于PNI陰性亞組,且差異顯著(P=0.034)。Cox多因素分析顯示,神經(jīng)侵犯不是影響宮頸癌術(shù)后患者生存的獨(dú)立預(yù)后因素(P0.05)。結(jié)論:宮頸癌神經(jīng)侵犯降低患者5年無復(fù)發(fā)生存率,且在維吾爾族患者中顯著,但其不能作為判斷宮頸癌預(yù)后的獨(dú)立指標(biāo)。因此,神經(jīng)侵犯可能是宮頸癌的新候選危險(xiǎn)因素。
[Abstract]:Objective: there is no consistent conclusion on the prognosis of cervical cancer patients with peripheral nerve invasion (perineural invasion,PNI). The purpose of this study was to investigate the influence of cervical cancer peripheral nerve invasion on prognosis and the difference between Uygur and Han nationalities. Methods: the clinicopathological data of 413 cases (IB-IIB stage) after radical resection of cervical cancer from 2009 to 2014 were analyzed retrospectively. There were 198 Uygur patients and 215 Han patients. To study the relationship between cervical carcinoma neuroinvolvement and other clinicopathological features and its prognostic significance. Results: there were 8. 0% (33 / 413) cases of cervical carcinoma with nerve invasion, which were associated with lymph node metastasis, mass 鈮，

本文編號(hào)：2358166