【摘要】：目的檢測先兆早產(chǎn)患者外周血促腎上腺皮質(zhì)激素釋放激素(CRH)濃度,探討其濃度與先兆早產(chǎn)癥狀的相關(guān)性及影響其濃度的因素,以探討CRH濃度作為預(yù)測早產(chǎn)指標(biāo)的可行性。方法選取先兆早產(chǎn)住院孕婦及不足月非先兆早產(chǎn)原因住院孕婦共45例,其中先兆早產(chǎn)組(孕28~36周)22例,對(duì)照組(孕28~36周、無先兆早產(chǎn)癥狀的孕婦)23例。采每位受試對(duì)象抗凝外周血5 m L,分離血漿,采用ELISA法測定CRH濃度。結(jié)果先兆早產(chǎn)組孕婦外周血CRH濃度與對(duì)照組孕婦相比顯著升高(P0.01)。先兆早產(chǎn)組與對(duì)照組的新生兒出生Apgar評(píng)分(1和5 min)均7分,且2組比較新生兒出生Apgar評(píng)分無統(tǒng)計(jì)學(xué)差異(P0.05)。先兆早產(chǎn)組與對(duì)照組比較,宮頸Bishop評(píng)分無統(tǒng)計(jì)學(xué)差異(P0.05),先兆早產(chǎn)組中CRH濃度與宮頸Bishop評(píng)分無明顯關(guān)系(P0.05)。先兆早產(chǎn)組與對(duì)照組中,雙胎者與單胎者相比,胎膜早破者與非胎膜早破者相比,CRH濃度的差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論血漿CRH濃度明顯升高是先兆早產(chǎn)的顯著指標(biāo)。血漿CRH濃度不影響新生兒出生狀態(tài)和宮頸成熟度,但受妊娠胎兒數(shù)影響,且與胎膜早破密切相關(guān)。血漿CRH濃度有望成為預(yù)測先兆早產(chǎn)的指標(biāo),但其影響因素較多,應(yīng)在分析其影響因素后進(jìn)一步研究其預(yù)測定量值。
[Abstract]:Objective to detect the concentration of adrenocorticotropin releasing hormone (CRH) in peripheral blood of patients with threatened preterm delivery, to explore the correlation between the concentration of CRH and symptoms of threatened preterm delivery and the factors affecting its concentration, and to explore the feasibility of using CRH concentration as a predictor of preterm labor. Methods A total of 45 hospitalized pregnant women with threatened preterm delivery and unthreatened preterm delivery were selected, including 22 patients in threatened preterm delivery group (2836 weeks of pregnancy) and 23 in control group (2836 weeks of gestation without symptoms of preterm delivery). 5 mL of anticoagulant peripheral blood was collected from each subject, plasma was isolated and CRH concentration was determined by ELISA method. Results the concentration of CRH in peripheral blood of threatened premature delivery group was significantly higher than that of control group (P0.01). The neonatal Apgar score (1 and 5 min) in the threatened preterm delivery group and the control group were 7, and there was no significant difference in the neonatal Apgar score between the two groups (P0.05). There was no significant difference in cervical Bishop score between threatened premature delivery group and control group (P0.05). There was no significant relationship between CRH concentration and cervical Bishop score in threatened preterm delivery group (P0.05). In the threatened premature delivery group and the control group, there were significant differences in the concentration of CRH between twin and single fetus, premature rupture of membranes and non-premature rupture of membranes (P0.05). Conclusion the increase of plasma CRH concentration is a significant indicator of threatened premature delivery. The concentration of plasma CRH does not affect the birth status and cervical maturity of the newborn, but it is affected by the number of fetuses in pregnancy and is closely related to premature rupture of membranes. Plasma CRH concentration is expected to be a predictor of preterm labor, but there are many influencing factors, so we should further study the quantitative value of plasma CRH after analyzing its influencing factors.
【作者單位】： 中國醫(yī)科大學(xué)附屬盛京醫(yī)院婦產(chǎn)科;
【分類號(hào)】：R714.21

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