【摘要】：目的： 調(diào)查卵巢癌患者的生活狀況，了解卵巢癌患者的癥狀群，分析影響患者生活質(zhì)量的因素，為緩解卵巢癌患者癥狀、提高其生活質(zhì)量提供參考。 方法： 采用隨機抽樣法，對2012年5月至2013年10月就診于吉林省長春市2家三級甲等醫(yī)院的卵巢癌患者94例（其中初發(fā)病者43例、復發(fā)患者51例）進行問卷調(diào)查，共獲得有效問卷180份。采用社會人口學資料調(diào)查表、世界衛(wèi)生組織生存質(zhì)量測定量表(WHOQOL一100)和卵巢癌特異性問卷應用SPSS7.0對資料進行分析，對社會人口學資料調(diào)查表、癥狀和生活質(zhì)量進行描述性分析；對生活質(zhì)量的組間差異采用單因素方差分析；把生活質(zhì)量作為因變量，將其相關(guān)因素作為自變量，進行多元逐步回歸法分析卵巢癌患者生活質(zhì)量的影響因素。 結(jié)果： 1、卵巢癌患者得分較高的癥狀是乏力、嘔吐、悲傷感、胃口差及脫發(fā)；這些癥狀對生理狀況和感情狀況的影響較大，對社會/家庭狀況的影響較小。 2、卵巢癌患者術(shù)后及化療期間常見的癥狀群有5個，包括：疼痛相關(guān)的癥狀群，心理癥狀群，圍絕經(jīng)期癥狀，胃腸道相關(guān)癥狀群，化療副作用癥狀群。 3、卵巢癌患者生存質(zhì)量的平均得分為94.58±4.25。各維度得分由低到高依次為生理狀況、卵巢癌特異模塊、功能狀況、情感狀況及社會/家庭狀況�；颊叩哪挲g、家庭月收入、醫(yī)保類型、體力狀況、化療時間點、有無復發(fā)及臨床分期對患者的生存質(zhì)量有顯著的影響，而文化程度、居住地、職業(yè)、婚姻狀況、病理類型及有無慢性疾病對患者的生存質(zhì)量無統(tǒng)計學意義。 4、疼痛相關(guān)的癥狀群與生理狀況及卵巢癌特異性模塊相關(guān)；圍絕經(jīng)癥狀群與生理狀況相關(guān)；心理癥狀群與情感狀況及社會/家庭狀況相關(guān)；胃腸道相關(guān)癥狀群與生理狀況功能狀況及卵巢癌特異性模塊相關(guān)；化療副作用癥狀群與生理狀況、功能狀況及卵巢癌特異性模塊相關(guān)。 結(jié)論： 1、卵巢癌患者術(shù)后及化療期間常見的癥狀群有5個，包括：疼痛相關(guān)的癥狀群，心理癥狀群，，圍絕經(jīng)期癥狀，胃腸道相關(guān)癥狀群，化療副作用癥狀群。 2、不同治療階段存在不同的癥狀群，且其強度及群內(nèi)構(gòu)成成分不同。 3、卵巢癌患者的生存質(zhì)量受多種因素的影響，癥狀群與生存質(zhì)量呈負相關(guān)，對其進行有效地干預可提高患者的生存質(zhì)量。
[Abstract]:Objective: to investigate the living conditions of patients with ovarian cancer, to understand the symptom group of patients with ovarian cancer, and to analyze the factors affecting the quality of life of patients with ovarian cancer, so as to provide a reference for alleviating the symptoms of patients with ovarian cancer and improving their quality of life. Methods: from May 2012 to October 2013, 94 patients with ovarian cancer (43 patients with initial onset and 51 patients with recurrence) who were admitted to 2 Grade 3A hospitals in Changchun, Jilin Province, were investigated by random sampling. A total of 180 valid questionnaires were obtained. Social demographics questionnaire, World Health Organization quality of Life scale (WHOQOL -100) and Ovarian Cancer specificity questionnaire were used to analyze the data. Descriptive analysis of symptoms and quality of life; Univariate ANOVA was used to analyze the difference of quality of life among groups, and quality of life was regarded as dependent variable and related factors were taken as independent variables to analyze the influencing factors of quality of life of ovarian cancer patients by multivariate stepwise regression method. Results: 1 the symptoms with higher scores of ovarian cancer were fatigue, vomiting, sadness, poor appetite and alopecia. 2. There are 5 common symptom groups in patients with ovarian cancer after operation and during chemotherapy, including: pain related symptom group, psychological symptom group, peri-menopausal symptom group, gastrointestinal tract related symptom group, chemotherapy side effect symptom group. The mean quality of life score of ovarian cancer patients was 94.58 鹵4.25. The scores of each dimension from low to high were physiological status, ovarian cancer specific module, functional status, emotional status and social / family status. Age, monthly income of family, type of medical insurance, physical condition, time point of chemotherapy, recurrence and clinical stage had significant effects on patients' quality of life, while education, residence, occupation, marital status, There was no significant difference in quality of life (QOL) between pathological types and chronic diseases. (4) pain related symptom group was related to physiological status and ovarian cancer specific module, perimenopausal symptom group was related to physiological condition, psychological symptom group was related to emotional state and social / family condition. Gastrointestinal related symptom group was related to physiological status and ovarian cancer specific module, and chemotherapy side effect symptom group was related to physiological status, function status and ovarian cancer specificity module. Conclusion: 1. There are 5 common symptom groups in patients with ovarian cancer after operation and during chemotherapy, including: pain related symptom group, psychological symptom group, peri-menopausal symptom group, gastrointestinal tract related symptom group, chemotherapy side effect symptom group. 2. There are different symptom groups in different treatment stages, and their strength and composition are different. 3. The quality of life of ovarian cancer patients was affected by many factors, and the symptom group was negatively correlated with the quality of life. Effective intervention could improve the quality of life.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R737.31

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