【摘要】：目的探討人絨毛膜促性腺激素(h CG)注射后不同時間受精對體外受精-胚胎移植(IVF-ET)治療患者實驗室指標(biāo)及臨床指標(biāo)的影響。方法選取行IVF-ET治療并符合納入標(biāo)準(zhǔn)的患者200例,根據(jù)h CG注射后受精時間不同隨機(jī)分為4組:h CG注射后38.0~39.0 h受精為A組;注射h CG后39.1~40.0 h受精為B組、h CG注射后40.1~41.0 h受精為C組、h CG注射后41.1~42.0 h受精為D組,每組50例,觀察并比較四組間實驗室指標(biāo)及臨床指標(biāo)。結(jié)果可用胚胎率B組(65.7%)、C組(63.3%)、D組(66.8%)均高于A組(55.5%)(P0.05);優(yōu)質(zhì)胚胎率A組(50.6%)顯著低于C組(60.2%)與D組(63.6%)(P0.05),B組(54.3%)明顯低于D組(P0.05);C組獲得了較好的臨床結(jié)局,臨床妊娠率(50.0%)和著床率(34.2%)較高,流產(chǎn)率(9.1%)較低。正常受精率、正常卵裂率、臨床妊娠率、著床率以及流產(chǎn)率組間比較,差異均無統(tǒng)計學(xué)意義(P0.05)。結(jié)論在一定時間范圍內(nèi)(38.0~42.0 h),隨著h CG注射后受精時間的延長,優(yōu)質(zhì)胚胎率呈增高趨勢;本中心IVF-ET治療患者的最佳受精時間為h CG注射后40.1~41.0 h,此時受精患者有較高的臨床妊娠率,較低的早期流產(chǎn)率及較好的臨床妊娠結(jié)局。
[Abstract]:Objective to investigate the effects of different time fertilization after human chorionic gonadotropin (h CG) injection on laboratory and clinical indexes of patients undergoing in vitro fertilization and embryo transfer (IVF-ET). Methods 200 patients who were treated with IVF-ET and met the inclusion criteria were randomly divided into 4 groups according to the time of fertilization after: h CG injection, 38.0 and 39.0 h after: h CG injection. 40.0 h after CG injection, 41.0 h after, h CG injection in group B, 41.0 h after injection of, h CG in group C, 42.0 h after injection of, h CG in group C, 50 cases in each group. The laboratory indexes and clinical indexes were observed and compared among the four groups. Results the usable embryo rate in group B (65.7%), C) was higher than that in group A (66.8%) (63.3%), D) (P0.05). The rate of high quality embryos in group A (50.6%) was significantly lower than that in group C (60.2%) and group D (63.6%) (P0.05) in), B group (54.3%). In group C, the clinical outcome was better. The clinical pregnancy rate (50.0%) and implantation rate (34.2%) were higher and the abortion rate (9.1%) was lower. There was no significant difference in normal fertilization rate, normal cleavage rate, clinical pregnancy rate, implantation rate and abortion rate (P0.05). Conclusion within a certain time range (38.0 h), 42.0 h), the rate of high quality embryos increased with the prolongation of fertilization time after CG injection. The best fertilization time of IVF-ET in this center was 40.1 鹵41.0 hours after CG injection. At this time, the fertilization patients had higher clinical pregnancy rate, lower early abortion rate and better clinical pregnancy outcome.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院生殖中心;南京市婦幼保健院;
【分類號】：R714.8

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