發(fā)布時間：2018-11-06 19:55

【摘要】：目的探討在控制性超排卵(COH)中體外受精-胚胎移植(IVF-ET)不同卵巢反應患者hCG注射日孕酮水平對妊娠結(jié)局的影響。方法回顧性分析行IVF-ET的1077例患者的資料,根據(jù)獲卵數(shù)將卵巢反應分為高反應組、正常反應組和低反應組。均采用黃體期長方案控制性促排卵�；瘜W發(fā)光法檢測hCG日孕酮(P)水平。根據(jù)P水平分組:3.18 nmol/L、3.18~3.98 nmol/L、3.99~4.77 nmol/L、4.78~5.57 nmol/L、5.58~6.36 nmol/L、6.36 nmol/L。分別比較不同反應組新鮮周期的妊娠率、獲卵數(shù)、優(yōu)胚數(shù)及妊娠結(jié)局。結(jié)果 1高反應組及正常反應組6.36 nmol/L患者臨床妊娠率最低(18.75%,3/16;12.50%,2/16),低反應組P4.77 nmol/L患者臨床妊娠率低(9.09%,1/11);2高反應組及正常反應組P≤6.36 nmol/L組臨床妊娠率(44.88%,114/238;42.19%,278/659)較6.36 nmol/L組高(18.75%,3/16;12.5%,2/16;P0.05);3低反應組P≤4.77 nmol/L組臨床妊娠率較4.77 nmol/L組高(41.35%,55/133;6.67%,3/16;P0.05)。各組獲卵數(shù)和優(yōu)胚數(shù)比較,差異均無統(tǒng)計學意義(P0.05)。結(jié)論 hCG日血清P水平明顯升高可影響IVF-ET的妊娠率。卵巢不同反應者其P升高影響妊娠率的切點值不同。
[Abstract]:Objective to investigate the effect of progesterone level on pregnancy outcome in patients with different ovarian reactions during in vitro fertilization and embryo transfer (IVF-ET) in controlled hyperovulation (COH). Methods the data of 1077 patients with IVF-ET were analyzed retrospectively. The ovarian response was divided into high response group, normal response group and low response group according to the number of oocytes obtained. Ovulation was controlled by long luteal phase regimen. The level of progesterone (P) in hCG was detected by chemiluminescence assay. Grouped according to P level: 3.18 nmol/L,3.18~3.98 nmol/L,3.99~4.77 nmol/L,4.78~5.57 nmol/L,5.58~6.36 nmol/L,6.36 nmol/L. The pregnancy rate, the number of eggs, the number of embryos and the outcome of pregnancy were compared in different response groups. Results (1) the clinical pregnancy rate of 6.36 nmol/L patients in the high response group and the normal reaction group was the lowest (18.7575 / 3 / 16 12.50 / 2 / 16), while in the low reaction group P4.77 nmol/L was low (9.09 / 11). 2 the clinical pregnancy rate (P 鈮，

本文編號：2315305