Th17細胞在婦產(chǎn)科疾病中作用研究進展
發(fā)布時間:2018-11-02 18:10
【摘要】:正T淋巴細胞是人體內(nèi)免疫系統(tǒng)的重要組成部分,CD4+T細胞作為效應(yīng)T細胞的重要成員之一,過去將CD4+T細胞分為Th1和Th2兩類細胞亞群[1]。Th1細胞主要介導細胞免疫,主要分泌白細胞介素2(IL-2)、腫瘤壞死因子β(TNF-β)、干擾素γ(IFN-γ)等。其中IFN-γ占主導地位,具有誘導腫瘤細胞凋亡、抑制血管生成,激活抗腫瘤活性的作用。尤其是在細菌、病毒及原蟲感染中起保護作用[2]。Th2細胞主要分泌IL-4、IL-5、IL-10和IL-13,介導體液免疫反應(yīng)。其中IL-4和IL-5起主要作用,其
[Abstract]:Positive T lymphocytes are an important part of human immune system. CD4 T cells are one of the important members of effector T cells. In the past, CD4 T cells were divided into two subgroups of Th1 and Th2. Th1 cells mainly mediated cellular immunity. Interleukin 2 (IL-2), tumor necrosis factor 尾 (TNF- 尾) and interferon 緯 (IFN- 緯) were secreted. IFN- 緯 plays an important role in inducing tumor cell apoptosis, inhibiting angiogenesis and activating antitumor activity. Especially in bacteria, viruses and protozoa infection. Th2 cells mainly secrete IL-4,IL-5,IL-10 and IL-13, mediated humoral immune response. Among them, IL-4 and IL-5 play a major role.
【作者單位】: 青島大學附屬醫(yī)院婦科;山東大學齊魯醫(yī)院婦產(chǎn)科;
【分類號】:R71
[Abstract]:Positive T lymphocytes are an important part of human immune system. CD4 T cells are one of the important members of effector T cells. In the past, CD4 T cells were divided into two subgroups of Th1 and Th2. Th1 cells mainly mediated cellular immunity. Interleukin 2 (IL-2), tumor necrosis factor 尾 (TNF- 尾) and interferon 緯 (IFN- 緯) were secreted. IFN- 緯 plays an important role in inducing tumor cell apoptosis, inhibiting angiogenesis and activating antitumor activity. Especially in bacteria, viruses and protozoa infection. Th2 cells mainly secrete IL-4,IL-5,IL-10 and IL-13, mediated humoral immune response. Among them, IL-4 and IL-5 play a major role.
【作者單位】: 青島大學附屬醫(yī)院婦科;山東大學齊魯醫(yī)院婦產(chǎn)科;
【分類號】:R71
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