【摘要】：目的研究分析甲狀腺自身抗體抗甲狀腺過氧化物酶抗體(TPOAb)與復(fù)發(fā)性流產(chǎn)的相關(guān)性,為臨床診斷復(fù)發(fā)性流產(chǎn)尋找客觀的數(shù)據(jù)指標(biāo)。方法選擇2012年3月至2014年5月在該院進(jìn)行體檢的婦產(chǎn)科門診甲狀腺功能正常的孕早期婦女1 016例作為研究對(duì)象,篩選出其中的90例流產(chǎn)患者分成兩組,原發(fā)性流產(chǎn)組60例,復(fù)發(fā)性流產(chǎn)組30例,另選90例體檢健康的育齡女性作為對(duì)照組,統(tǒng)計(jì)并對(duì)比各組的TPOAb陽性例數(shù),計(jì)算比率;記錄各組TPOAb水平,同時(shí)分析TPOAb與復(fù)發(fā)性流產(chǎn)的相關(guān)性。結(jié)果復(fù)發(fā)性流產(chǎn)組的TPOAb陽性率為46.67%,顯著高于原發(fā)性流產(chǎn)組的25.00%,以及對(duì)照組的4.44%;同時(shí)原發(fā)性流產(chǎn)組的TPOAb陽性率亦顯著高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。復(fù)發(fā)性流產(chǎn)組的TPOAb水平顯著高于原發(fā)性流產(chǎn)組和對(duì)照組的水平;同時(shí)原發(fā)性流產(chǎn)組的TPOAb濃度水平亦顯著高于對(duì)照組的水平,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。隨訪不良妊娠發(fā)生情況,以復(fù)發(fā)性流產(chǎn)為不良妊娠事件,并根據(jù)Spearman法分析相關(guān)性可知,隨著TPOAb水平的增加,復(fù)發(fā)性流產(chǎn)的發(fā)生率增高,二者之間呈正相關(guān)(r=0.764,P=0.000)。結(jié)論監(jiān)測(cè)患者TPOAb水平,可較好地呈現(xiàn)復(fù)發(fā)性流產(chǎn)的癥狀情況。
[Abstract]:Objective to study the correlation between thyroid autoantibody (TPOAb) and recurrent abortion and to find objective data for clinical diagnosis of recurrent abortion. Methods from March 2012 to May 2014, 1016 pregnant women with normal thyroid function in gynecology and obstetrics outpatient clinic were selected as the study objects. 90 of them were divided into two groups, 60 cases of primary abortion group. Thirty cases of recurrent abortion group and 90 healthy women of childbearing age were selected as control group. The positive cases of TPOAb in each group were counted and compared, and the ratio of TPOAb was calculated. The levels of TPOAb were recorded and the correlation between TPOAb and recurrent abortion was analyzed. Results the positive rate of TPOAb in recurrent abortion group was 46.67, which was significantly higher than that in primary abortion group (25.00) and control group (4.44%). At the same time, the positive rate of TPOAb in primary abortion group was significantly higher than that in control group, the difference was statistically significant (P0.05). The level of TPOAb in recurrent abortion group was significantly higher than that in primary abortion group and control group, and the level of TPOAb in primary abortion group was significantly higher than that in control group (P0.05). According to the analysis of Spearman method, the incidence of recurrent abortion increased with the increase of TPOAb level, and there was a positive correlation between them (r = 0.764P = 0.000). Conclusion Monitoring the level of TPOAb can better present the symptoms of recurrent abortion.
【作者單位】： 貴州省興義市人民醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R714.21

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