【摘要】：目的研究分析甲狀腺自身抗體抗甲狀腺過氧化物酶抗體(TPOAb)與復發(fā)性流產(chǎn)的相關性,為臨床診斷復發(fā)性流產(chǎn)尋找客觀的數(shù)據(jù)指標。方法選擇2012年3月至2014年5月在該院進行體檢的婦產(chǎn)科門診甲狀腺功能正常的孕早期婦女1 016例作為研究對象,篩選出其中的90例流產(chǎn)患者分成兩組,原發(fā)性流產(chǎn)組60例,復發(fā)性流產(chǎn)組30例,另選90例體檢健康的育齡女性作為對照組,統(tǒng)計并對比各組的TPOAb陽性例數(shù),計算比率;記錄各組TPOAb水平,同時分析TPOAb與復發(fā)性流產(chǎn)的相關性。結果復發(fā)性流產(chǎn)組的TPOAb陽性率為46.67%,顯著高于原發(fā)性流產(chǎn)組的25.00%,以及對照組的4.44%;同時原發(fā)性流產(chǎn)組的TPOAb陽性率亦顯著高于對照組,差異均有統(tǒng)計學意義(均P0.05)。復發(fā)性流產(chǎn)組的TPOAb水平顯著高于原發(fā)性流產(chǎn)組和對照組的水平;同時原發(fā)性流產(chǎn)組的TPOAb濃度水平亦顯著高于對照組的水平,差異均有統(tǒng)計學意義(均P0.05)。隨訪不良妊娠發(fā)生情況,以復發(fā)性流產(chǎn)為不良妊娠事件,并根據(jù)Spearman法分析相關性可知,隨著TPOAb水平的增加,復發(fā)性流產(chǎn)的發(fā)生率增高,二者之間呈正相關(r=0.764,P=0.000)。結論監(jiān)測患者TPOAb水平,可較好地呈現(xiàn)復發(fā)性流產(chǎn)的癥狀情況。
[Abstract]:Objective to study the correlation between thyroid autoantibody (TPOAb) and recurrent abortion and to find objective data for clinical diagnosis of recurrent abortion. Methods from March 2012 to May 2014, 1016 pregnant women with normal thyroid function in gynecology and obstetrics outpatient clinic were selected as the study objects. 90 of them were divided into two groups, 60 cases of primary abortion group. Thirty cases of recurrent abortion group and 90 healthy women of childbearing age were selected as control group. The positive cases of TPOAb in each group were counted and compared, and the ratio of TPOAb was calculated. The levels of TPOAb were recorded and the correlation between TPOAb and recurrent abortion was analyzed. Results the positive rate of TPOAb in recurrent abortion group was 46.67, which was significantly higher than that in primary abortion group (25.00) and control group (4.44%). At the same time, the positive rate of TPOAb in primary abortion group was significantly higher than that in control group, the difference was statistically significant (P0.05). The level of TPOAb in recurrent abortion group was significantly higher than that in primary abortion group and control group, and the level of TPOAb in primary abortion group was significantly higher than that in control group (P0.05). According to the analysis of Spearman method, the incidence of recurrent abortion increased with the increase of TPOAb level, and there was a positive correlation between them (r = 0.764P = 0.000). Conclusion Monitoring the level of TPOAb can better present the symptoms of recurrent abortion.
【作者單位】： 貴州省興義市人民醫(yī)院內(nèi)分泌科;
【分類號】：R714.21

【參考文獻】

相關期刊論文 前6條

1 朱姝;陸啟濱;;抗磷脂抗體導致妊娠丟失動物模型研究進展[J];重慶醫(yī)學;2010年24期

2 谷春會;梁文君;付璐璐;鄭連文;;復發(fā)性自然流產(chǎn)危險因素的研究進展[J];中華男科學雜志;2013年08期

3 王立英;張濤;王洪波;;抗甲狀腺球蛋白抗體與抗甲狀腺過氧化物酶抗體在甲狀腺功能異常診斷中的應用[J];臨床和實驗醫(yī)學雜志;2012年13期

4 馬英英;夏舟嵐;陳惠娟;陸月紅;;亞臨床甲狀腺功能減退癥與自然流產(chǎn)史的關系探討[J];中華全科醫(yī)學;2014年03期

5 潘云芳;;抗甲狀腺球蛋白抗體和抗甲狀腺過氧化物酶抗體檢測對甲狀腺疾病的診斷價值[J];醫(yī)學理論與實踐;2010年07期

6 沙靜;劉福民;王文;劉小云;朱學文;;免疫球蛋白聯(lián)合絨毛膜促性腺激素對原因不明復發(fā)性流產(chǎn)患者外周血Th17/Treg平衡的影響[J];中華臨床醫(yī)師雜志(電子版);2014年01期

【共引文獻】

相關期刊論文 前10條

1 陸燕婷;趙晉華;汪太松;程斌;;393例孕婦促甲狀腺激素及甲狀腺過氧化物酶抗體篩查結果分析[J];標記免疫分析與臨床;2013年01期

2 初平;王h，

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