【摘要】：目的探討拉貝洛爾對中重度妊娠期高血壓疾病患者心腎功能及妊娠結(jié)局的影響及機(jī)制。方法選擇中重度妊娠期高血壓疾病患者120例,隨機(jī)分為觀察組與對照組各60例。對照組給予25%硫酸鎂溶液60 m L+5%葡萄糖注射液500 m L靜脈滴注,1次/d;甲基多巴250 mg/次口服,2次/d。觀察組給予硫酸鎂治療,方法同對照組;另外加拉貝拉爾50 mg+5%葡萄糖注射液500 m L靜脈滴注,1次/d。兩組均治療1周。對比兩組治療前后腎功能指標(biāo)[血清胱抑素C(Cys C)、尿微量白蛋白(m ALB)、24 h尿蛋白]、心功能指標(biāo)[肌鈣蛋白T(c Tn T)/血漿鈉尿肽(BNP)]及炎性因子[血清C反應(yīng)蛋白(CRP)、腫瘤壞死因子α(TNF-α)]水平、平均動脈壓(MAP)、妊娠結(jié)局。結(jié)果治療后兩組血清Cys C、m ALB、24 h尿蛋白、血清c Tn T、BNP、CRP、TNF-α水平與治療前比較,P均0.05;治療后觀察組以上指標(biāo)與對照組比較,P均0.05。兩組產(chǎn)后出血、羊水Ⅲ度渾濁、終止妊娠、胎兒窘迫發(fā)生率及新生兒出生5 min Apgar評分比較,P均0.05。結(jié)論拉貝洛爾可減輕中重度妊娠期高血壓疾病患者心腎功能損傷,改善妊娠結(jié)局;其機(jī)制可能與下調(diào)患者體內(nèi)血清炎性因子水平有關(guān)。
[Abstract]:Objective to investigate the effect and mechanism of Labe lol on heart and kidney function and pregnancy outcome in patients with moderate and severe hypertensive disorder complicating pregnancy. Methods 120 patients with moderate and severe hypertensive disorder complicating pregnancy were randomly divided into two groups: the observation group (n = 60) and the control group (n = 60). The control group was given 60% magnesium sulfate solution 60 mL 5% glucose injection 500ml intravenously once a day, and methyldopa 250 mg/ orally twice a day. The observation group was treated with magnesium sulfate in the same way as the control group, in addition, Galabella 50 mg 5% glucose injection 500ml intravenously, once a day. Both groups were treated for 1 week. Renal function index [serum cystatin C (Cys C), urine microalbumin (m ALB), 24 h urine protein], cardiac function index [troponin T (c Tn T) / plasma natriuretic peptide (BNP)] and inflammatory factor [serum C-reactive protein (CRP), tumor necrosis factor 偽 (TNF- 偽)] were compared before and after treatment. Mean arterial pressure (MAP),) pregnancy outcome. Results after treatment, the levels of serum Cys Cam ALB,24 h urine protein, serum c Tn TNPP, CRPNP TNF- 偽 in the two groups were compared with those before treatment (P 0.05), and the above indexes in the observation group were higher than those in the control group (P 0.05). There were significant differences in postpartum hemorrhage, 鈪，

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