發(fā)布時(shí)間：2018-10-16 10:59

【摘要】：目的：了解新輔助化療反應(yīng)性對(duì)宮頸癌患者遠(yuǎn)期預(yù)后的影響。方法：電子檢索PubMed、MEDLINE、Web of Knowledge、Google、中國(guó)知網(wǎng)數(shù)據(jù)庫(kù)、維普科技期刊數(shù)據(jù)庫(kù)搜索文獻(xiàn)，根據(jù)異質(zhì)性檢測(cè)決定使用固定或隨機(jī)效應(yīng)模型進(jìn)行效應(yīng)量比值比（OR）合并統(tǒng)計(jì)，用RevMan.5.2統(tǒng)計(jì)學(xué)軟件進(jìn)行統(tǒng)計(jì)處理。結(jié)果：共有14篇文章共1326名患者納入，化療有效反應(yīng)率波動(dòng)在39.8%-97.3%（實(shí)體瘤評(píng)價(jià)標(biāo)準(zhǔn)評(píng)價(jià)）及27.6%、28.6%（手術(shù)標(biāo)本病理診斷評(píng)價(jià)），2-year PFS/OS效應(yīng)量比值比OR分別為4.67（95%CI3.35-6.77；Z=8.68P=0.00）、4.39（95%CI2.53-7.61；Z=5.26P=0.00），，5-year PFS/OS效應(yīng)量比值比OR分別為5.36（95%CI3.59-7.99；Z=8.23P=0.00）、5.80（95%CI3.83-8.79；Z=8.30P=0.00）。X2檢驗(yàn)及I2檢驗(yàn)提示各納入研究無(wú)顯著異質(zhì)性，漏斗圖提示無(wú)顯著發(fā)表偏倚，通過(guò)改變效應(yīng)統(tǒng)計(jì)模型、去除大樣本進(jìn)行敏感性分析，提示該meta分析結(jié)果穩(wěn)定。結(jié)論：宮頸癌術(shù)前新輔助化療有效的化療反應(yīng)性可改善遠(yuǎn)期預(yù)后。
[Abstract]:Objective: to investigate the effect of neoadjuvant chemotherapeutic reactivity on long-term prognosis in patients with cervical cancer. Methods: PubMed,MEDLINE,Web of Knowledge,Google, China knowledge Network Database and Wiper Science and Technology Journal Database were searched electronically. According to the heterogeneity test, fixed or random effect models were used to combine the ratio of effect volume to (OR). RevMan.5.2 statistical software was used to deal with the statistics. Results: a total of 1326 patients were included in 14 articles. The effective response rate of chemotherapy varied from 39.8% to 97.3% (evaluation criteria for solid tumors) and 27.62.6% (pathological diagnosis of surgical specimens). The ratio of 2-year PFS/OS effect to OR was 4.67 (95CI3.35-6.77Z8.68P0.00) and 4.39 (95CI2.53-7.61), respectively. Z=5.26P=0.00), the ratio of 5-year PFS/OS effect volume to OR was 5.36 (95CI3.59-7.99) and 5.80 (95CI3.83-8.79ZH 8.30P0.00) respectively. X2 test and I2 test showed that there was no significant heterogeneity in each study, and funnel diagram showed no significant bias. The sensitivity analysis was carried out by changing the statistical model of effect and removing large samples. These results suggest that the meta analysis results are stable. Conclusion: preoperative neoadjuvant chemotherapy can improve the long-term prognosis of cervical cancer.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R737.33

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