【摘要】：目的探討宮頸癌患者手術(shù)前后及術(shù)后發(fā)生感染時(shí)T淋巴細(xì)胞免疫功能的變化,以指導(dǎo)術(shù)后臨床藥物的使用。方法選擇2012年10月-2013年9月在婦科宮頸癌ⅠA~ⅡA期行廣泛子宮切除+盆腔淋巴結(jié)清掃術(shù)患者50例,其中33例術(shù)后無(wú)感染患者為手術(shù)Ⅰ組,17例合并術(shù)后感染患者為手術(shù)Ⅱ組;另選取20名健康女性為對(duì)照Ⅰ組及20例子宮肌瘤行全子宮切除術(shù)患者為對(duì)照Ⅱ組,采用ELISA法檢測(cè)各組血清中γ干擾素(IFN-γ)、白細(xì)胞介素2(IL-2)和腫瘤壞死因子α(TNF-α);采用流式細(xì)胞術(shù)檢測(cè)外周血中IFN-γ+CD4+、IL-2+CD4+和TNF-α+CD4+等T淋巴細(xì)胞亞群。結(jié)果手術(shù)Ⅰ、Ⅱ組的宮頸癌患者IFN-γ+CD4+、IL-2+CD4+和TNF-α+CD4+T淋巴細(xì)胞及其分泌的IFN-γ、IL-2和TNF-α水平在術(shù)前顯著低于對(duì)照Ⅰ、Ⅱ組(P0.05);手術(shù)Ⅰ、Ⅱ組的以上各項(xiàng)免疫指標(biāo)在術(shù)后顯著升高(P0.05),且術(shù)后合并感染的手術(shù)Ⅱ組明顯高于未合并感染的手術(shù)Ⅰ組(P0.05)。結(jié)論宮頸癌患者體內(nèi)T淋巴細(xì)胞分泌細(xì)胞因子功能受抑制;術(shù)后T淋巴細(xì)胞免疫功能有恢復(fù)趨勢(shì),而感染進(jìn)一步增強(qiáng)免疫反應(yīng)。
[Abstract]:Objective to investigate the changes of T lymphocyte immune function in patients with cervical cancer before and after operation. Methods from October 2012 to September 2013, 50 patients with gynecological cervical cancer underwent extensive hysterectomy and pelvic lymph node dissection. 33 patients without infection after operation were selected as group 鈪，

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