【摘要】：目的探討輔助生殖技術致妊娠的早期流產絨毛染色體異常情況。方法將622例孕早期流產的孕婦分為兩組,其中輔助生殖技術致妊娠的早期流產孕婦156例為ART組,自然妊娠早期流產孕婦466例為對照組。分別對兩組孕婦的絨毛細胞進行絨毛細胞分離、培養(yǎng)及染色體分析。結果對照組正常核型299例,異常核型167例,染色體異常類型最多見的是染色體數(shù)量異常,以47,XX/XY,+22、47,XX/XY,+16多見,其他可見三體和嵌合體;ART組正常核型87例,異常核型69例,以常染色體三體最多見共計33例,最多見的三體為47,XX/XY,+22、47,XX/XY,+16,三倍體型4例、染色體多態(tài)性2例、嵌合體型3例、單體型4例、四倍體型2例;對照組不同年齡(40歲、≥40歲)間染色體異常率差異有統(tǒng)計學意義(P0.05),ART組不同年齡(40歲、≥40歲)間染色體異常率差異有統(tǒng)計學意義(P0.05),ART組與對照組的染色體異常率差異無統(tǒng)計學意義(P0.05)。結論與自然妊娠相比,輔助生殖技術妊娠并不增加孕早期自然流產胚胎染色體異常的發(fā)生率,染色體異常與年齡有關。
[Abstract]:Objective to investigate the chromosomal abnormalities of villi in early abortion induced by assisted reproductive technique. Methods 622 pregnant women with early abortion were divided into two groups: ART group (ART group) and control group (466 cases). The chorionic villi of two groups of pregnant women were isolated, cultured and chromosome analyzed. Results in the control group, there were 299 normal karyotypes and 167 abnormal karyotypes. The most common chromosomal abnormalities were chromosome quantitative abnormalities, with 47 / XXXY, 22 / 47 / XXXXXY, 16, and other trisomy and chimerism, while 87 normal karyotypes and 69 abnormal karyotypes were found in the ART group. There were 33 cases of autosomal trisomy, the most common trisomy was 47XXXXXY, 2247xr XY, 16s, triploid 4, chromosome polymorphism 2, chimera 3, haplotype 4, tetraploid 2, control group 40 years old. There was significant difference in chromosomal abnormality rate between), ART group and control group (P0.05). There was no significant difference between), ART group and control group (P0.05). Conclusion compared with natural pregnancy, assisted reproductive pregnancy does not increase the incidence of chromosomal abnormalities in embryos of early spontaneous abortion, and chromosomal abnormalities are related to age.
【作者單位】： 廣州醫(yī)科大學附屬第三醫(yī)院婦產科研究所實驗部廣東省產科重大疾病重點實驗室廣東省普通高校生殖與遺傳重點實驗室;
【分類號】：R714.21

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