絕經(jīng)前后女性維生素D營養(yǎng)狀況及其與血脂代謝相關(guān)性研究
發(fā)布時間：2018-10-08 20:58
【摘要】：目的描述絕經(jīng)前后女性血清維生素D水平的分布特點并探討其影響因素;初步探討絕經(jīng)前、圍絕經(jīng)期、絕經(jīng)后女性血清維生素D與血脂之間的關(guān)系。方法采用橫斷面調(diào)查研究方法,以2014年10月-11月在安徽醫(yī)科大學(xué)第一附屬醫(yī)院健康體檢中心進行體檢的35歲以上健康女性為研究對象。使用自行設(shè)計的調(diào)查問卷進行問卷調(diào)查,并收集其體格檢查資料和臨床生化指標。問卷調(diào)查內(nèi)容包括一般人口學(xué)特征等基本信息,生活習(xí)慣,月經(jīng)生育史,既往疾病史等;體格檢查包括身高、體重、血壓等;臨床生化指標包括:25(OH)D、FBG、TC、TG、LDL-C、HDL-C。應(yīng)用SPSS16.0軟件包進行t檢驗、單因素方差分析、偏相關(guān)分析和二元Logistic回歸分析。結(jié)果共獲取符合條件的研究對象302例,平均年齡為48.1±7.6歲。48%的女性為家庭婦女,文化程度總體較低,74.8%的調(diào)查者自述經(jīng)濟狀況中等。絕經(jīng)前、圍絕經(jīng)期以及絕經(jīng)后女性分別占35.1%、30.5%以及34.4%。研究對象的血清25(OH)D水平的均值為(15.21±4.76)ng/m L。維生素D水平正常者僅有2例(0.66%),不足者44例(14.57%),缺乏者256例(84.77%)。絕經(jīng)前、圍絕經(jīng)期、絕經(jīng)后女性組血清25(OH)D水平依次升高,組間差異有統(tǒng)計學(xué)意義(P=0.013),但不同年齡、職業(yè)、學(xué)歷、經(jīng)濟狀況的人群,組間血清25(OH)D水平均無統(tǒng)計學(xué)差異;是否飲酒、不同睡眠時間、是否經(jīng)常進行戶外鍛煉以及不同體力活動強度組間的血清25(OH)D水平也均無統(tǒng)計學(xué)差異;服用鈣劑者血清25(OH)D水平高于未服用者,差異有統(tǒng)計學(xué)意義(P=0.003),但不同飲食習(xí)慣組間血清25(OH)D水平無統(tǒng)計學(xué)差異。二元Logistic回歸分析顯示是否服用鈣劑以及年齡是維生素D是否缺乏的獨立影響因素。絕經(jīng)前、圍絕經(jīng)期、絕經(jīng)后三組SBP、FBG、TC、LDL-C水平依次升高,差異有統(tǒng)計學(xué)意義(P0.05)。偏相關(guān)分析顯示絕經(jīng)后女性血清25(OH)D水平與TG水平呈負相關(guān)(r=-0.203,P=0.045);圍絕經(jīng)期女性血清25(OH)D水平與HDL-C水平呈負相關(guān)(r=-0.274,P=0.010)。按照血脂水平不同分組比較,302例研究對象組間血清25(OH)D水平無統(tǒng)計學(xué)差異,但按月經(jīng)情況進行分層后,絕經(jīng)后女性不同TG水平組間血清25(OH)D水平差異有統(tǒng)計學(xué)意義(P=0.030)。二元非條件Logistic回歸分析顯示血清25(OH)D是TG的獨立影響因素。結(jié)論絕經(jīng)前后女性普遍存在維生素D營養(yǎng)缺乏,年齡、服用鈣劑是維生素D水平的影響因素。絕經(jīng)前、圍絕經(jīng)期女性血清25(OH)D與血脂代謝之間無相關(guān)性,絕經(jīng)后女性低的維生素D水平可能對TG產(chǎn)生不利影響。
[Abstract]:Objective to study the relationship between serum vitamin D and blood lipid in premenopausal, perimenopausal and postmenopausal women. Methods A cross-sectional investigation was conducted on healthy women over 35 years old who were examined in the Health examination Center of the first affiliated Hospital of Anhui Medical University from October to November 2014. The self-designed questionnaire was used to collect the data of physical examination and clinical biochemical index. The contents of the questionnaire included general demographic characteristics, life habits, menstrual history, history of illness, etc. Physical examination included height, weight, blood pressure, and clinical biochemical indexes included: 1. T test, single factor analysis of variance, partial correlation analysis and binary Logistic regression analysis were carried out with SPSS16.0 software package. Results A total of 302 eligible subjects were obtained. The average age was 48.1 鹵7.6 years old. 48% of the women were housewives, and 74.8% of the respondents with lower education level reported moderate self-reported economic status. Before menopause, 35. 1% and 34. 4% of peri-menopausal and postmenopausal women accounted for 35. 5% and 34. 4% respectively. The mean value of serum 25 (OH) D level was (15.21 鹵4.76) ng/m / L. There were only 2 cases (0.66%) with normal vitamin D level, 44 cases (14.57%) with deficiency and 256 cases (84.77%) with deficiency. The serum 25 (OH) D level of premenopausal, peri-menopausal and postmenopausal women increased in turn, and the difference was statistically significant (P < 0.013), but there was no significant difference in serum 25 (OH) D levels among groups with different age, occupation, educational background and financial status. There was also no significant difference in serum 25 (OH) D levels between the groups with different sleep time, whether or not exercising outdoors and with different physical activity intensity. The serum 25 (OH) D level of patients taking calcium was higher than that of those who did not take calcium. The difference was statistically significant (P0. 003), but there was no significant difference in serum 25 (OH) D level among different dietary habits. Binary Logistic regression analysis showed that calcium intake and age were independent factors for vitamin D deficiency. The levels of SBP,FBG,TC,LDL-C in premenopausal, peri-menopausal and postmenopausal groups increased in turn, and the difference was statistically significant (P0.05). Partial correlation analysis showed that there was a negative correlation between serum 25 (OH) D level and TG level in postmenopausal women (r = 0.203), and a negative correlation between serum 25 (OH) D level and HDL-C level in postmenopausal women (r = -0.274). There was no significant difference in serum 25 (OH) D level among 302 subjects according to the blood lipid level, but there was significant difference in serum 25 (OH) D level among postmenopausal women with different TG levels after menstrual stratification (P0. 030). Binary non-conditional Logistic regression analysis showed that serum 25 (OH) D was an independent factor for TG. Conclusion Vitamin D deficiency is common in postmenopausal women. Age and calcium are the influencing factors of vitamin D level in premenopausal and postmenopausal women. There was no correlation between serum 25 (OH) D and lipid metabolism in postmenopausal women. Low vitamin D level in postmenopausal women might have a negative effect on TG.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R711
本文編號：2258241
[Abstract]:Objective to study the relationship between serum vitamin D and blood lipid in premenopausal, perimenopausal and postmenopausal women. Methods A cross-sectional investigation was conducted on healthy women over 35 years old who were examined in the Health examination Center of the first affiliated Hospital of Anhui Medical University from October to November 2014. The self-designed questionnaire was used to collect the data of physical examination and clinical biochemical index. The contents of the questionnaire included general demographic characteristics, life habits, menstrual history, history of illness, etc. Physical examination included height, weight, blood pressure, and clinical biochemical indexes included: 1. T test, single factor analysis of variance, partial correlation analysis and binary Logistic regression analysis were carried out with SPSS16.0 software package. Results A total of 302 eligible subjects were obtained. The average age was 48.1 鹵7.6 years old. 48% of the women were housewives, and 74.8% of the respondents with lower education level reported moderate self-reported economic status. Before menopause, 35. 1% and 34. 4% of peri-menopausal and postmenopausal women accounted for 35. 5% and 34. 4% respectively. The mean value of serum 25 (OH) D level was (15.21 鹵4.76) ng/m / L. There were only 2 cases (0.66%) with normal vitamin D level, 44 cases (14.57%) with deficiency and 256 cases (84.77%) with deficiency. The serum 25 (OH) D level of premenopausal, peri-menopausal and postmenopausal women increased in turn, and the difference was statistically significant (P < 0.013), but there was no significant difference in serum 25 (OH) D levels among groups with different age, occupation, educational background and financial status. There was also no significant difference in serum 25 (OH) D levels between the groups with different sleep time, whether or not exercising outdoors and with different physical activity intensity. The serum 25 (OH) D level of patients taking calcium was higher than that of those who did not take calcium. The difference was statistically significant (P0. 003), but there was no significant difference in serum 25 (OH) D level among different dietary habits. Binary Logistic regression analysis showed that calcium intake and age were independent factors for vitamin D deficiency. The levels of SBP,FBG,TC,LDL-C in premenopausal, peri-menopausal and postmenopausal groups increased in turn, and the difference was statistically significant (P0.05). Partial correlation analysis showed that there was a negative correlation between serum 25 (OH) D level and TG level in postmenopausal women (r = 0.203), and a negative correlation between serum 25 (OH) D level and HDL-C level in postmenopausal women (r = -0.274). There was no significant difference in serum 25 (OH) D level among 302 subjects according to the blood lipid level, but there was significant difference in serum 25 (OH) D level among postmenopausal women with different TG levels after menstrual stratification (P0. 030). Binary non-conditional Logistic regression analysis showed that serum 25 (OH) D was an independent factor for TG. Conclusion Vitamin D deficiency is common in postmenopausal women. Age and calcium are the influencing factors of vitamin D level in premenopausal and postmenopausal women. There was no correlation between serum 25 (OH) D and lipid metabolism in postmenopausal women. Low vitamin D level in postmenopausal women might have a negative effect on TG.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R711
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相關(guān)期刊論文 前2條
1 張艷玲;馬書赫;張栩;于春曉;趙家軍;;山東地區(qū)中老年人群維生素D缺乏情況及其與高血壓的關(guān)系[J];山東醫(yī)藥;2014年14期
2 Lidija Klampfer;;Vitamin D and colon cancer[J];World Journal of Gastrointestinal Oncology;2014年11期
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