【摘要】：目的探討原因不明復(fù)發(fā)性流產(chǎn)(unexplained recurrent spontaneous abortion,URSA)的發(fā)生與記憶濾泡性輔助T(memory Tfh)細(xì)胞表達(dá)異常是否存在關(guān)聯(lián)。方法收集15例染色體正常的URSA為流產(chǎn)組,并以15例正常人工流產(chǎn)患者為正常對(duì)照組。分離所有患者外周血單個(gè)核細(xì)胞及蛻膜組織免疫細(xì)胞,用流式細(xì)胞術(shù)(FCM)檢測(cè)上述細(xì)胞中CD4+CXCR5+memory Tfh以及CD4+CXCR5+PD-1+memory Tfh細(xì)胞水平。結(jié)果流產(chǎn)組蛻膜局部CD4+CXCR5+memory Tfh以及CD4+CXCR5+PD-1+memory Tfh細(xì)胞水平顯著高于正常對(duì)照組(P0.05)。流產(chǎn)組外周血CD4+CXCR5+memory Tfh以及CD4+CXCR5+PD-1+memory Tfh細(xì)胞水平與正常對(duì)照組無明顯差異(P0.05)。結(jié)論早孕婦女蛻膜局部memory Tfh細(xì)胞數(shù)量增多可能與URSA發(fā)生有關(guān),母-胎界面的免疫異常可能導(dǎo)致URSA的發(fā)生。
[Abstract]:Objective to investigate the relationship between the occurrence of unexplained recurrent abortion (unexplained recurrent spontaneous abortion,URSA) and abnormal expression of memory follicular assistant T (memory Tfh) cells. Methods 15 cases of URSA with normal chromosome were collected as abortion group and 15 cases of normal induced abortion as normal control group. Peripheral blood mononuclear cells (PBMC) and decidua tissue immunocytes were isolated from all patients. The levels of CD4 CXCR5 memory Tfh and CD4 CXCR5 PD-1 memory Tfh cells in these cells were detected by flow cytometry (FCM). Results the levels of CD4 CXCR5 memory Tfh and CD4 CXCR5 PD-1 memory Tfh cells in decidua of abortion group were significantly higher than those in normal control group (P0.05). There was no significant difference in the levels of CD4 CXCR5 memory Tfh and CD4 CXCR5 PD-1 memory Tfh cells between the abortion group and the normal control group (P0.05). Conclusion the increase in the number of memory Tfh cells in decidua of early pregnant women may be related to the occurrence of URSA, and the immunologic abnormality of maternal-fetal interface may lead to the occurrence of URSA.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院婦產(chǎn)科;
【分類號(hào)】：R714.21

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曾琪 ,華克勤;再論多囊卵巢與復(fù)發(fā)性流產(chǎn)[J];國(guó)外醫(yī)學(xué).婦產(chǎn)科學(xué)分冊(cè);2000年06期

2 朱亮亮;朱付凡;;早期復(fù)發(fā)性流產(chǎn)的系統(tǒng)論思考[J];醫(yī)學(xué)與哲學(xué)(臨床決策論壇版);2007年10期

3 廖秀k，

本文編號(hào)：2252299