【摘要】：目的：分析高強度聚焦超聲治療子宮肌瘤及子宮腺肌病的臨床療效及其不良反應(yīng)的發(fā)生率。方法：回顧性研究我院2009年1月至2012年9月130例子宮肌瘤及子宮腺肌病患者高強度聚焦超聲治療前及治療后隨訪1、3、6、12個月的臨床資料,子宮肌瘤和子宮腺肌病治療的療效評價采用超聲、超聲造影、彩色多普勒血流信號、MRI、細(xì)胞學(xué)檢查比較治療前及治療后隨訪中臨床癥狀改善情況,肌瘤或子宮體積的大小,超聲造影圖像,病灶內(nèi)部血流及回聲,病變組織細(xì)胞結(jié)構(gòu)的改變來進(jìn)行評價。分析治療期間和治療后并發(fā)癥及不良反應(yīng)的發(fā)生率。結(jié)果：治療后,76例經(jīng)量增多的子宮肌瘤及子宮腺肌病的患者,治療后12個月減少到原來的14.5%；40例痛經(jīng)的子宮腺肌病患者,治療后12個月減少到原來的20%,40例子宮腺肌病患者增大的子宮體積明顯縮小(P0.05)。治療后第1、3、6、12個月平均縮小率分別為11.1%、22.0%、29.4%、39.0%。90例子宮肌瘤患者103個肌瘤體積明顯縮小(P0.05),治療后第1、3、6、12個月平均縮小率分別為45.7%、63.4%、74.3%、80.4%。治療后與治療前相比瘤體內(nèi)無灌注、回聲增強與彩色血流治療后大部分消失,細(xì)胞學(xué)檢查后發(fā)現(xiàn)治療后病灶細(xì)胞破壞與組織壞死等變化。治療中患者無嚴(yán)重的不良反應(yīng)發(fā)生。結(jié)論：高強度聚焦超聲治療子宮肌瘤及子宮腺肌病是一種安全有效的無創(chuàng)治療方法。
[Abstract]:Objective: to analyze the clinical efficacy and incidence of adverse reactions of high intensity focused ultrasound (HIFU) in the treatment of uterine leiomyoma and adenomyosis. Methods: the clinical data of 130 patients with uterine leiomyoma and adenomyosis from January 2009 to September 2012 were retrospectively studied. The therapeutic effects of hysteromyoma and adenomyosis were evaluated by ultrasound, contrast-enhanced ultrasound, color Doppler flow imaging and MRI.The cytological examination was used to compare the improvement of clinical symptoms, the size of myoma or uterine volume before and after treatment. Contrast-enhanced imaging, intrafocal blood flow and echo, pathological changes in tissue and cell structure were evaluated. The incidence of complications and adverse reactions during and after treatment was analyzed. Results: after treatment, 76 cases of uterine leiomyoma and adenomyosis were reduced to 14.5 cases of dysmenorrhea in 12 months after treatment. After 12 months of treatment, the uterine volume of 40 patients with adenomyosis was significantly reduced (P0.05). After treatment, the mean reduction rates of the first trimester and the 12th month were 11.1and 22.0and 29.49.0.The volume of 103 myomas in 90 patients with hysteromyoma decreased significantly (P0.05), and the average reduction rate at 12 months after treatment was 45.73.474.3c80.4, respectively. After treatment, there was no perfusion in the tumor, echo enhancement and color blood flow disappeared after treatment. Cytological examination showed the changes of cell destruction and tissue necrosis after treatment. No serious adverse reactions occurred in the treatment. Conclusion: high intensity focused ultrasound is a safe and effective method for the treatment of uterine leiomyoma and adenomyosis.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.33

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 段麗君;;腹腔鏡子宮肌瘤剔除術(shù)75例臨床分析[J];腹腔鏡外科雜志;2006年04期

2 李兆清;侯理達(dá);李珍;鄭衛(wèi);李莉;;子宮動脈栓塞材料的研究進(jìn)展[J];材料導(dǎo)報;2013年05期

3 許永華;符忠祥;楊利霞;陳文直;劉映江;葉方偉;王智彪;;MRI導(dǎo)航和溫度監(jiān)控下高強度聚焦超聲治療子宮肌瘤[J];介入放射學(xué)雜志;2010年11期

4 劉艷林;吳光平;張焰;;超聲消融治療子宮肌瘤后早期療效觀察[J];臨床超聲醫(yī)學(xué)雜志;2012年08期

5 王寶菊;;不同微創(chuàng)術(shù)式剝除子宮肌瘤的臨床療效觀察[J];內(nèi)蒙古中醫(yī)藥;2012年21期

6 李荔霞;張為民;黃雪琴;朱賢勝;;超聲造影對高強度聚焦超聲治療腹腔惡性腫瘤的療效評價[J];現(xiàn)代腫瘤醫(yī)學(xué);2009年03期

7 張華;張保燕;;消融刀治療子宮肌瘤60例[J];實用醫(yī)藥雜志;2013年04期

8 孫海燕;黃淑華;瑪依努爾;李麗;;高強度聚焦超聲治療較大體積子宮肌瘤54例臨床研究[J];新疆醫(yī)學(xué);2007年03期

9 夏文霞;葉新民;雷建明;;彩色多普勒超聲對高強度聚焦超聲治療子宮肌瘤、腺肌瘤的療效評價[J];醫(yī)學(xué)影像學(xué)雜志;2010年03期

10 劉新華;董子啟;;子宮肌瘤發(fā)病機制的研究進(jìn)展[J];中國醫(yī)療前沿;2008年06期

，

本文編號：2238016