【摘要】：目的：測(cè)定子宮內(nèi)膜異位癥(endometriosis,EMS)患者血清及腹腔液中CA125、CA199及白細(xì)胞介素-6（IL-6）的濃度，探討三種因子的變化與EMS的關(guān)系，尋找診斷及檢測(cè)疾病發(fā)展較為準(zhǔn)確的方法。方法：選取了40例EMS患者(實(shí)驗(yàn)組)，按r-AFS分期法分為I-IV期，其中EMSI、II期16例，III、IV期24例；40例子宮肌瘤患者(對(duì)照組)。采用免疫化學(xué)發(fā)光法檢測(cè)兩組患者血清及腹腔液中三種因子的濃度，比較兩者的差別。結(jié)果：1、EMS患者血清CA125、CA199及IL-6的檢測(cè)值、陽(yáng)性率均顯著增高于對(duì)照組；2、EMS患者腹腔液CA125、CA199及IL-6的檢測(cè)值、陽(yáng)性率均顯著增高于對(duì)照組；3、EMSI、II期患者血清中三種因子檢測(cè)與對(duì)照組無(wú)顯著性差異（P0.05）。而腹腔液中三種因子水平顯著高于對(duì)照組（P0.01）；EMSIII、IV期患者血清與腹腔液三種因子均高于對(duì)照組（P0.05）；EMSI、II期患者與III、IV期患者血清檢測(cè)差異顯著（P0.05）；4、血清CA125、CA199及IL-6聯(lián)合測(cè)定用于診斷EMS的敏感性及特異性分別為55%及100%；5、術(shù)前、術(shù)后六月血清CA125、CA199及IL-6比較差異有顯著性，P0.01。結(jié)論：EMS患者血清和腹腔液中CA125、CA199及IL-6與EMS的發(fā)生、發(fā)展密切相關(guān)，三種因子血清學(xué)聯(lián)合檢測(cè)可提高子宮內(nèi)膜異位癥診斷的特異性；通過(guò)測(cè)定血清CA125、CA199及IL-6可作為其病情評(píng)估及判斷其預(yù)后的指標(biāo)。
[Abstract]:Objective: to determine the concentration of CA125,CA199 and interleukin-6 (IL-6) in serum and peritoneal fluid of patients with endometriosis (endometriosis,EMS), to explore the relationship between the changes of three factors and EMS, and to find a more accurate method for the diagnosis and detection of the development of endometriosis. Methods: forty patients with EMS (experimental group) were divided into I-IV stage according to r-AFS staging. Among them, there were 16 cases with EMSI,II stage and 24 cases with uterine leiomyoma (control group). The concentration of three factors in serum and celiac fluid of the two groups were detected by immunochemiluminescence method. Results the positive rates of CA125,CA199 and IL-6 in the patients with CA125,CA199 were significantly higher than those in the control group (P < 0.01), and the positive rates were significantly higher than those in the control group (P < 0.01). 3 there was no significant difference between the three factors in the serum of EMSI stage II patients and the control group (P0.05). The levels of three factors in the peritoneal fluid were significantly higher than those in the control group (P0.01) and the serum levels of the three factors in the patients with EMSIIIIV stage IV were significantly higher than those in the control group (P0.05) and the serum levels of the patients with EMSI stage II and III,IV were significantly higher than those in the control group (P0.05). 4. The sensitivity and specificity of serum CA125,CA199 and IL-6 in the diagnosis of EMS were 55% and 100%, respectively. There was a significant difference in serum CA125,CA199 and IL-6 between preoperative and postoperative 6 months (P 0.01). Conclusion the occurrence and development of CA125,CA199 and IL-6 in serum and peritoneal fluid are closely related to the development of EMS. The combined detection of three factors can improve the specificity of diagnosis of endometriosis. Serum CA125,CA199 and IL-6 can be used as an index to evaluate the disease and to judge the prognosis.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R711.71

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