【摘要】：目的探討妊娠期高血壓疾病(HDCP)患者血漿氨基末端腦鈉尿肽前體(NT-proBNP)及高敏C反應蛋白(hsCRP)與疾病嚴重程度的關系。方法選取2012年3月至2014年6月97例因妊娠期間初發(fā)高血壓就診患者為研究對象,按入院時病情分為重度子癇前期組(重度子癇前期患者33例)和非重度子癇前期組(妊娠高血壓及輕度子癇前期患者64例),另外選取同期同孕周正常健康妊娠婦女60人為對照組。記錄孕婦收縮壓及舒張壓水平,檢測孕婦血漿NT-proBNP、hsCRP;將HDCP孕婦血漿NT-proBNP、hsCRP按照中位數分為兩組,比較各組出現不同病情高血壓疾病的構成比。結果與對照組比較,重度子癇前期組及非重度子癇前期組孕婦的血漿NT-proBNP、hsCRP水平、24h定量尿蛋白、收縮壓、舒張壓較高(均P0.05),但重度子癇前期組與非重度子癇前期組間上述指標水平的差異無統(tǒng)計學意義(P0.05)。與NT-proBNP≤263.6ng/L組比較,NT-proBNP263.6ng/L組孕婦hsCRP水平較高(P0.05),重度子癇前期構成比亦較高(P0.05);與hsCRP≤6.83 mg/L組比較,hsCRP6.83mg/L組孕婦血漿NT-proBNP水平較高(P0.05),重度子癇前期構成比亦較高(P0.05)。結論 HDCP患者血漿NT-proBNP、hsCRP水平隨著病情發(fā)展不斷升高,與重度子癇的發(fā)生密切相關。
[Abstract]:Objective to investigate the relationship between plasma amino-terminal brain natriuretic peptide precursor (NT-proBNP) and Gao Min C-reactive protein (Gao Min C reactive protein (hsCRP) and severity of hypertensive disorder complicating pregnancy (HDCP). Methods from March 2012 to June 2014, 97 patients with primary hypertension during pregnancy were selected as subjects. The patients were divided into severe preeclampsia group (33 patients with severe preeclampsia) and non-severe preeclampsia group (64 patients with pregnancy-induced hypertension and mild preeclampsia). 60 female as control group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded, plasma NT-proBNPhsCRP was measured, and plasma NT-proBNPhsCRP was divided into two groups according to median. Results compared with the control group, the plasma NT-proBNPhsCRP levels of pregnant women in severe preeclampsia group and non-severe preeclampsia group were determined by 24 h quantitative urine protein and systolic blood pressure (SBP). Diastolic blood pressure was higher (P0.05), but there was no significant difference between severe preeclampsia group and non-severe preeclampsia group (P0.05). Compared with NT-proBNP 鈮，

本文編號：2199061