發(fā)布時間：2018-08-20 19:23

【摘要】：目的調(diào)查南寧市婦女高危型人乳頭狀病毒(HPV)感染狀態(tài)及危險因素。方法 2014年1~6月,在該院婦科門診就診自愿參加進行宮頸癌機會性篩查及問卷調(diào)查的婦女431名為研究對象,收集她們的人口學(xué)信息和相關(guān)危險因素信息,并行常規(guī)婦科檢查、生殖道微生物檢測、宮頸細胞第2代雜交捕獲技術(shù)(HC2)檢測、細胞學(xué)檢查。對可疑宮頸上皮內(nèi)瘤變或?qū)m頸癌患者行陰道鏡檢查活檢,并進行組織病理學(xué)診斷。結(jié)果 431名調(diào)查對象中,高危型HPV感染54例,感染率12.53%。在宮頸病變組與宮頸正常組中,高危型HPV陽性率分別為87.50%和9.64%,兩者比較差異有統(tǒng)計學(xué)意義(P0.05)。單因素及多因素研究分析,多個性伴侶(≥2個)和病原菌感染(尤其是細菌性陰道炎)是高危型HPV感染的高危因素。對陰道微生態(tài)環(huán)境的多因素分析顯示,病原菌感染和細菌性陰道病是HPV病毒感染的高危因素。結(jié)論宮頸病變組中HPV感染率高于宮頸正常組,而初次性生活年齡早、多個性伴侶、病原菌感染、細菌性陰道病是HPV感染的危險因素。
[Abstract]:Objective to investigate the status and risk factors of high-risk human papillary virus (HPV) infection in women in Nanning. Methods from January to June 2014, 431 women who volunteered to take part in the chance screening and questionnaire survey of cervical cancer in gynecological outpatient clinic of our hospital were selected as study subjects. Their demographic information and related risk factors were collected, and routine gynecological examinations were performed. Genital tract microorganism detection, cervical cell second generation hybridization capture technique (HC2) detection, cytological examination. Colposcopy biopsy and histopathological diagnosis were performed in patients with suspected cervical intraepithelial neoplasia or cervical cancer. Results among 431 subjects, 54 cases were high risk HPV infection, the infection rate was 12.53%. The positive rates of high-risk HPV were 87.50% and 9.64 in cervical lesion group and normal cervical group respectively, the difference was statistically significant (P0.05). Univariate and multivariate analysis showed that multiple personality partners (鈮，

本文編號：2194734