發(fā)布時(shí)間：2018-08-20 16:23

【摘要】：目的探討子癇前期(Preeclampsia,PE)的發(fā)生與飲食習(xí)慣、膳食攝入及血生化指標(biāo)的關(guān)系,為指導(dǎo)孕期合理膳食、糾正不良生活習(xí)慣及預(yù)防子癇前期的發(fā)生提供理論依據(jù)。方法收集2016年3月至2016年12月在鄭州大學(xué)第一附屬醫(yī)院產(chǎn)科住院分娩的PE患者167例為病例組,按照年齡±3歲、孕周±2周,隨機(jī)選取同月份住院分娩的血壓正常孕婦167例作為對(duì)照組,采用自編的《孕期健康危險(xiǎn)因素評(píng)估問卷》調(diào)查病例組及對(duì)照組的社會(huì)人口學(xué)統(tǒng)計(jì)資料、近三個(gè)月膳食攝入情況及相關(guān)的實(shí)驗(yàn)室檢查結(jié)果,運(yùn)用Epidata3.1進(jìn)行資料的錄入,SPSS17.0建立數(shù)據(jù)庫并進(jìn)行統(tǒng)計(jì)分析,檢驗(yàn)水準(zhǔn)α=0.05。結(jié)果:1.病例組與對(duì)照組在分娩孕周、身高、分娩體重、孕前BMI、孕期體重變化(包括早、中、晚期)、高血壓家族史、產(chǎn)次、孕次、文化程度及飲食口味上差異有統(tǒng)計(jì)學(xué)意義(P0.05),經(jīng)非條件logistic回歸分析發(fā)現(xiàn)孕前BMI[OR=1.28(95%CI1.13~1.45)]、孕次[OR=0.33(95%CI0.17~0.68)]、高血壓家族史[OR=2.30(95%CI1.31~4.04)]及文化程度[OR=0.38(95%CI0.20~0.73)]與PE的發(fā)病風(fēng)險(xiǎn)有關(guān)。2.病例組各食物成分及營(yíng)養(yǎng)素?cái)z入量普遍低于對(duì)照組,尤其是在薯類、水果、禽畜肉類、蛋白質(zhì)、各種維生素及礦物質(zhì)的攝入量上差異有統(tǒng)計(jì)學(xué)意義(P0.05),經(jīng)logistic回歸分析發(fā)現(xiàn),薯類[OR=0.86(95%CI0.75~0.98)]、畜禽肉類[OR=0.86(95%CI0.75~0.99)]、維生素C[OR=0.87(95%CI0.75~0.99)]及鋅[OR=0.67(95%CI0.48~0.93)]的攝入量可能是PE的保護(hù)因素。3.兩組人群國(guó)際膳食質(zhì)量指數(shù)(Dietary quality index-international,DQI-I)較低,病例組評(píng)分低于對(duì)照組(P0.05),經(jīng)logistic回歸分析發(fā)現(xiàn),DQI-I得分是PE發(fā)病的保護(hù)因素[OR=0.82(95%CI0.71~0.96)]。4.兩組孕婦血生化指標(biāo)差異也存在統(tǒng)計(jì)學(xué)意義(P0.05),經(jīng)過多因素logistic回歸分析發(fā)現(xiàn),血清白蛋白[OR=0.40(95%CI0.26~0.63)]、鉀[OR=1.48(95%CI1.20~1.81)]、鎂[OR=1.24(95%CI1.08~1.41)]及血紅蛋白[OR=2.26(95%CI 1.71~2.99)]水平與PE發(fā)病風(fēng)險(xiǎn)有關(guān)。結(jié)論:1.孕前BMI、高血壓家族史可能為PE的危險(xiǎn)因素,而孕次"f3次、文化程度可能為PE的保護(hù)因素。2.薯類、畜禽肉類、維生素C及鋅的攝入量可能為PE的保護(hù)因素。3.國(guó)際膳食質(zhì)量指數(shù)得分可能為PE的保護(hù)因素。4.血清鉀、鎂及血紅蛋白水平可能為PE的危險(xiǎn)因素,而血清白蛋白水平可能為PE的保護(hù)因素。
[Abstract]:Objective to explore the relationship between preeclampsia PE and dietary habits, dietary intake and blood biochemical indexes, so as to provide theoretical basis for guiding reasonable diet during pregnancy, correcting bad living habits and preventing preeclampsia. Methods from March 2016 to December 2016, 167 cases of PE patients who were hospitalized and delivered in obstetrics department of the first affiliated Hospital of Zhengzhou University were collected as the case group, according to age 鹵3 years, gestational week 鹵2 weeks. 167 normal pregnant women with normal blood pressure during the same month were randomly selected as the control group. The social demographic statistics of the case group and the control group were investigated by the self-designed questionnaire on risk factors of pregnancy. In the last three months, dietary intake and related laboratory examination results were used to establish the database with Epidata3.1 data input and SPSS 17.0, and the test level was 0. 05%. The result is 1: 1. The case group and the control group had a family history of hypertension, birth, pregnancy, BMIs before pregnancy, changes in weight during pregnancy (including early, middle, and late), family history of hypertension, delivery, pregnancy. There were significant differences in educational level and dietary taste (P0.05). BMI [OR=1.28 (95%CI1.13~1.45)], OR=0.33 (95%CI0.17~0.68), OR=2.30 (95%CI1.31~4.04) and education (OR=0.38 (95%CI0.20~0.73) were found to be associated with PE risk by non-conditional logistic regression analysis. The intake of food components and nutrients in the case group was generally lower than that in the control group, especially in potato, fruit, livestock meat, protein, various vitamins and minerals (P0.05), which were found by logistic regression analysis. The intake of OR=0.86 (95%CI0.75~0.98), OR=0.86 (95%CI0.75~0.99), OR=0.87 (95%CI0.75~0.99) and OR=0.67 (95%CI0.48~0.93) may be the protective factors of PE. The international dietary quality index (Dietary quality index-international DQI-I) of the two groups was lower than that of the control group (P0.05). The logistic regression analysis showed that the DQI-I score was the protective factor of PE [OR=0.82 (95%CI0.71~0.96)] .4. There was also significant difference in serum biochemical indexes between the two groups (P0.05). The levels of serum albumin [OR=0.40 (95%CI0.26~0.63)], potassium [OR=1.48 (95%CI1.20~1.81)], magnesium [OR=1.24 (95%CI1.08~1.41)] and hemoglobin [OR=2.26 (95%CI 1.71 鹵2.99)] were correlated with the risk of PE by multivariate logistic regression analysis. Conclusion 1. BMI before pregnancy, hypertension family history may be the risk factor of PE, and pregnant "f 3 times, education level may be the protective factor of PE. 2." The intake of potato, meat, vitamin C and zinc may be the protective factor of PE. The score of international dietary quality index may be the protective factor of PE. The levels of serum potassium, magnesium and hemoglobin may be the risk factors of PE, while serum albumin may be the protective factor of PE.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R714.244

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 孟濤;李輝;劉彤;潘莉莉;;脂聯(lián)素及氧化修飾低密度脂蛋白在子癇前期中的測(cè)定及意義[J];中國(guó)優(yōu)生與遺傳雜志;2006年06期

2 桑翠琴;張震宇;王淑珍;劉浩;郭淑麗;;重度子癇前期/子癇合并急性呼吸窘迫綜合征的診斷與處理[J];中國(guó)醫(yī)刊;2006年10期

3 趙桂花;;重度子癇前期與子癇82例臨床分析[J];臨床醫(yī)藥實(shí)踐雜志;2007年01期

4 楊小頎;嚴(yán)妮子;;子癇前期與血鈣水平相關(guān)性研究[J];實(shí)用臨床醫(yī)學(xué);2007年04期

5 楊小頎;嚴(yán)妮子;;子癇前期與血鈣水平相關(guān)性研究[J];四川生理科學(xué)雜志;2007年01期

6 陳茜;王澤華;;子癇前期的預(yù)測(cè)及預(yù)防[J];華中醫(yī)學(xué)雜志;2007年03期

7 朱倩;;對(duì)38例子癇前期(重)、子癇治愈的體會(huì)[J];實(shí)用預(yù)防醫(yī)學(xué);2007年05期

8 梁英;周麗麗;甘娟;姜碧洋;楊承東;;重度子癇前期在產(chǎn)科ICU監(jiān)護(hù)救治的臨床分析[J];中國(guó)婦幼保健;2008年19期

9 詹衛(wèi)星;鄭九生;;血管緊張素轉(zhuǎn)換酶基因多態(tài)性與重度子癇前期及腎功能損害的關(guān)系[J];江西醫(yī)藥;2008年08期

10 蔡穎;尹國(guó)武;姜鋒;李怡;閔保華;王s，

本文編號(hào)：2194255