【摘要】：目的:探討卵巢低反應(yīng)(poor ovarian response,POR)患者在體外受精/卵胞質(zhì)內(nèi)單精子顯微注射-胚胎移植(IVF/ICSI-ET)技術(shù)中應(yīng)用微刺激方案更合適的取卵時(shí)機(jī)。方法:回顧性分析接受微刺激方案IVF/ICSI-ET助孕的POR患者共363個(gè)周期的臨床資料,分為來(lái)曲唑(LE)+尿促性腺素(hMG)+后半程氯米芬片(CC)組(A組)和全程CC+hMG組(B組)。觀察分析臨床及實(shí)驗(yàn)室指標(biāo)、不同取卵時(shí)機(jī)獲卵情況及后續(xù)凍融胚胎移植(FET)周期的妊娠結(jié)局。結(jié)果:患者的Gn使用天數(shù)、扳機(jī)日E2、取卵前日E2、MⅡ卵率組間比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。取卵前日E2與扳機(jī)日E2相比上升者注射達(dá)菲林后33 h取卵獲卵情況要差于35 h和36 h取卵者(P0.05),而取卵前日E2與扳機(jī)日E2相比下降者,下降比例≤1/3者獲卵率要明顯優(yōu)于1/3者(P0.05)。結(jié)論:POR患者應(yīng)用微刺激方案時(shí),取卵前日E2與扳機(jī)日E2相比,上升者,可注射達(dá)菲林后35~36 h取卵;下降者,下降比例≤1/3,可33 h取卵,如下降比例1/3,則提示33 h后取卵獲卵情況差。
[Abstract]:Aim: to investigate the more suitable timing of microstimulation in vitro fertilization / intracytoplasmic sperm microinjection-embryo transfer (IVF/ICSI-ET) for patients with low ovarian response to (poor ovarian. Methods: the clinical data of 363 cycles of POR patients who received IVF/ICSI-ET were analyzed retrospectively. They were divided into (CC) group (group A) and CC hMG group (group B). The patients were divided into two groups: (CC) group (group A) and group B (group B). The clinical and laboratory indexes were observed and analyzed. The oocytes were obtained at different time and the pregnancy outcome of the (FET) cycle of subsequent frozen-thawed embryo transfer was observed and analyzed. Results: there were significant differences in the days of Gn use, the trigger day E _ 2 and the egg rate of E _ 2 M 鈪，

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