【摘要】：目的研究卵巢癌組織中癌超甲基化基因1蛋白和卵巢癌基因1蛋白的表達(dá)情況及其與卵巢癌病理特點(diǎn)的關(guān)系,探討其在卵巢癌中的意義。方法選擇2014-2015年在該院婦產(chǎn)科手術(shù)切除卵巢癌組織標(biāo)本63例和正常卵巢組織標(biāo)本63例作為研究對(duì)象。采用Western blot法測(cè)定卵巢癌組織和正常卵巢組織中癌超甲基化基因1蛋白和卵巢癌基因1蛋白的表達(dá)情況,并分析其與卵巢癌病理特點(diǎn)的關(guān)系。結(jié)果卵巢癌組織中癌超甲基化基因1蛋白、卵巢癌基因1蛋白的表達(dá)量明顯低于正常卵巢組織(P0.05)。癌超甲基化基因1蛋白在不同卵巢癌分期、不同分化程度和不同病理類(lèi)型中的表達(dá)量比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。在卵巢癌Ⅰ期中卵巢癌基因1蛋白的表達(dá)高于卵巢癌Ⅱ期和Ⅲ~Ⅳ期(P0.05),Ⅱ期的表達(dá)量高于Ⅲ~Ⅳ期(P0.05);高分化的表達(dá)量高于中分化和低分化(P0.05),中分化和低分化的表達(dá)量比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);卵巢癌基因1蛋白在卵巢癌不同病理類(lèi)型中的表達(dá)比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論癌超甲基化基因1蛋白失活可能只參與卵巢癌的發(fā)生,卵巢癌基因1蛋白和卵巢癌的發(fā)展有一定關(guān)系。
[Abstract]:Objective to study the expression of oncohypermethylated gene 1 protein and ovarian cancer gene 1 protein in ovarian cancer and their relationship with the pathological features of ovarian cancer and their significance in ovarian cancer. Methods 63 cases of ovarian cancer and 63 cases of normal ovarian tissue were selected in this hospital from 2014 to 2015. The expression of oncohypermethylated gene 1 protein and ovarian cancer gene 1 protein in ovarian cancer tissues and normal ovarian tissues were detected by Western blot method, and the relationship between the expression of hypermethylated gene 1 protein and the pathological characteristics of ovarian cancer was analyzed. Results the expression of oncohypermethylation gene 1 protein and ovarian cancer gene 1 protein in ovarian cancer tissues was significantly lower than that in normal ovarian tissues (P0.05). There was no significant difference in the expression of oncohypermethylated gene 1 protein in different stages, differentiation and pathological types of ovarian cancer (P0.05). The expression of gene 1 protein in ovarian cancer in stage 鈪，

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