【摘要】：目的探討同步放化療治療中晚期宮頸癌的臨床效果,分析宮頸癌并發(fā)局部感染的危險因素。方法選擇2010年1月-2011年1月于醫(yī)院就診的中晚期宮頸癌患者60例,隨機分為觀察組和對照組,各30例,對照組給予單純放射治療,觀察組給予同步放化療治療,比較兩組近期療效及不良反應,隨訪5年,比較兩組近遠期療效,分析感染相關影響因素。結果觀察組近期總有效率為93.33%顯著高于對照組的73.33%(P0.05),觀察組5年生存率為76.67%顯著高于對照組的53.33%(P0.05);觀察組局部復發(fā)率及遠處轉移率分別為16.67%,13.33%顯著低于對照組33.33%,26.67%(P0.05);對照組不良反應發(fā)生率13.33%,與觀察組23.33%差異無統(tǒng)計學意義。觀察組發(fā)生局部感染20例,感染率為66.67%;住院時間7d、合并有基礎疾病、醫(yī)護人員的手術不熟練、尿管留置時間3d、未應用抗菌藥物、FIGO分期IVb期是宮頸癌患者腔內放療并發(fā)局部感染的獨立危險因素(P0.05)。結論對中晚期宮頸癌患者采取同步放化療治療的療效較好,提高患者生存率,且耐受性較好。
[Abstract]:Objective to investigate the clinical effect of concurrent radiotherapy and chemotherapy in the treatment of advanced cervical cancer and to analyze the risk factors of cervical cancer complicated with local infection. Methods from January 2010 to January 2011, 60 patients with advanced cervical cancer were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30). The control group was treated with radiotherapy alone, and the observation group was treated with concurrent radiotherapy and chemotherapy. The short term curative effect and adverse reaction were compared between the two groups, followed up for 5 years, the near and long term curative effect were compared, and the influencing factors of infection were analyzed. Results the short-term total effective rate of the observation group was 93.33% significantly higher than that of the control group 73.33% (P0.05), the 5-year survival rate of the observation group was 76.67% significantly higher than that of the control group 53.33% (P0.05), the local recurrence rate and distant metastasis rate of the observation group were 13.33% significantly lower than that of the control group (26.67%), and the control group was significantly lower than the control group (P0.05). The incidence of adverse reaction was 13.33%, and there was no significant difference between observation group and observation group (23.33%). In the observation group, 20 cases of local infection occurred, the infection rate was 66.67%, the hospital stay was 7 days, the patients were complicated with basic diseases, and the medical staff were not skilled in operation. Urinary catheter indwelling time 3 days, no use of antibiotics Figo stage IVb stage of cervical cancer patients with intracavitary radiotherapy associated with local infection of the independent risk factors (P0.05). Conclusion simultaneous radiotherapy and chemotherapy is effective in the treatment of advanced cervical cancer, and the survival rate is improved.
【作者單位】： 鄭州大學附屬腫瘤醫(yī)院婦瘤科六病區(qū);
【分類號】：R737.33

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