【摘要】：目的探討廣州地區(qū)孕婦碘營(yíng)養(yǎng)狀況及其與甲狀腺功能的關(guān)系。方法選擇2012年3月至2014年2月在中山大學(xué)孫逸仙紀(jì)念醫(yī)院產(chǎn)檢的孕婦815為研究對(duì)象,進(jìn)行甲狀腺功能、抗甲狀腺過(guò)氧化物酶抗體(TPO-Ab)和尿碘的檢測(cè),結(jié)果異常者定期復(fù)查,密切監(jiān)測(cè)母胎情況,追蹤至妊娠終止。結(jié)果 815例無(wú)甲狀腺疾病史孕婦尿碘中位數(shù)(median urinary iodine,MUI)為197.0μg/L;其中碘缺乏者39.6%(323/815);碘適宜者20.9%(170/815);碘超足量者27.4%(223/815);碘過(guò)量者12.1%(99/815)。早中晚孕期MUI分別為208、182.5、174.5μg/L。不同碘營(yíng)養(yǎng)狀況下甲狀腺功能、甲狀腺疾病的患病率及TPO-Ab陽(yáng)性率的差異無(wú)統(tǒng)計(jì)學(xué)意義,均P0.05。結(jié)論孕婦碘營(yíng)養(yǎng)狀態(tài)為碘適宜,但個(gè)體間差異較大。不同碘營(yíng)養(yǎng)狀況下甲狀腺疾病的患病率無(wú)明顯差異,即輕度碘缺乏或碘過(guò)量不增加甲狀腺疾病的患病率。隨著孕周的增加,尿碘值逐漸下降,但都在碘適宜的范圍內(nèi)。
[Abstract]:Objective to investigate the iodine nutritional status of pregnant women in Guangzhou and its relationship with thyroid function. Methods from March 2012 to February 2014, 815 pregnant women in Sun Yat-sen Memorial Hospital, Sun Yat-sen University, were selected as subjects. Thyroid function, anti-thyroid peroxidase antibody (TPO-Ab) and urinary iodine were detected. Closely monitor the maternal and fetal conditions and follow up until the termination of pregnancy. Results the median urinary iodine (median urinary) of 815 pregnant women with no history of thyroid disease was 197.0 渭 g / L, in which 39.6% (32.3 / 815) were iodine deficient, 20.9% (170 / 815) were suitable for iodine, 27.4% (223815) were iodine excess, 12.1% (99r815) were iodine excess. The MUI of early, middle and late pregnancy was 208182.5174.5 渭 g / L, respectively. There was no significant difference in thyroid function, the prevalence of thyroid disease and the positive rate of TPO-Ab in different iodine nutrition status (P 0.05). Conclusion the iodine nutritional status of pregnant women is suitable for iodine, but there is great difference among individuals. There was no significant difference in the prevalence of thyroid diseases under different iodine nutrition conditions, that is, mild iodine deficiency or iodine excess did not increase the prevalence of thyroid diseases. With the increase of gestational weeks, urinary iodine values gradually decreased, but within the appropriate range of iodine.
【作者單位】： 中山大學(xué)附屬第三醫(yī)院婦產(chǎn)科;中山大學(xué)孫逸仙紀(jì)念醫(yī)院婦產(chǎn)科;
【基金】：廣東省科技計(jì)劃(2011B031800119)
【分類(lèi)號(hào)】：R714.256

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