【摘要】：目的血脂代謝異常所致的DNA損傷很可能與自然流產、胎膜早破、子癇前期等有著密切的關系。文中旨在探討肥胖產婦血脂水平與DNA損傷及總抗氧化能力水平的相關性。方法選取2011年8月至2012年8月于天津醫(yī)科大學第四中心臨床學院門診進行系統(tǒng)產科檢查的妊娠女性120例為研究對象,按照體重指數(shù)(BMI)分為肥胖組(BMI≥28 kg/m2,n=75)和正常組(BMI28 kg/m2且孕期體重增長≤15 kg,n=45)。比較分析2組血脂水平、DNA損傷情況與總抗氧化能力水平,并分析肥胖組血脂水平與DNA損傷及總抗氧化能力水平的相關性。結果肥胖組總膽固醇、三酰甘油、低密度脂蛋白膽固醇(LDL-c)水平均顯著高于正常組(P0.01、P0.01、P=0.004);高密度脂蛋白膽固醇水平顯著低于正常組(P=0.006)。肥胖組尾力矩顯著高于正常組(P0.01),且總抗氧化能力水平顯著高于正常組(P=0.000)。DNA損傷與總膽固醇、三酰甘油、LDL-c水平呈正相關(r=0.23,P=0.026;r=0.26,P=0.008;r=0.19,P=0.032);總抗氧化能力與三酰甘油水平呈正相關(r=0.32,P0.01)。結論肥胖產婦妊娠期間常出現(xiàn)血脂代謝紊亂及體內氧化與抗氧化水平失衡;DNA損傷與血清總膽固醇、三酰甘油、LDL-c水平呈顯著正相關,總抗氧化能力水平與三酰甘油水平呈顯著正相關。
[Abstract]:Objective DNA damage caused by dyslipidemia may be closely related to spontaneous abortion, premature rupture of membranes and preeclampsia. The aim of this study was to investigate the correlation between serum lipid levels and DNA damage and total antioxidant capacity in obese women. Methods from August 2011 to August 2012, 120 pregnant women who underwent systematic obstetrical examination in outpatient clinic of the fourth Center of Tianjin Medical University were selected as subjects. According to the body mass index (BMI), they were divided into obese group (BMI 鈮，

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