【摘要】：目的探討α-平滑肌肌動(dòng)蛋白(ɑ-smooth muscle actin,α-SMA)、成纖維細(xì)胞活化蛋白(fibroblast-activating protein,FAP)在正常子宮頸、子宮頸上皮內(nèi)瘤變(cervical intraepithelial neoplasias,CIN)、子宮頸浸潤(rùn)性癌組織的表達(dá),并分析二者表達(dá)與子宮頸浸潤(rùn)性癌臨床病理指標(biāo)、浸潤(rùn)轉(zhuǎn)移及預(yù)后的關(guān)系。方法應(yīng)用免疫組化Eli Vision兩步法檢測(cè)20例正常子宮頸、20例CIN及98例子宮頸浸潤(rùn)性癌組織中α-SMA和FAP的表達(dá)。比較三組中α-SMA和FAP的表達(dá)水平,以及二者與子宮頸浸潤(rùn)性癌臨床病理特征的相關(guān)性。結(jié)果α-SMA和FAP在正常子宮頸、CIN中不表達(dá),二者在子宮頸浸潤(rùn)性癌中均表達(dá)于腫瘤間質(zhì)成纖維細(xì)胞的胞質(zhì)內(nèi),FAP在腫瘤細(xì)胞中有少量表達(dá)。α-SMA在子宮頸浸潤(rùn)性癌間質(zhì)中的陽(yáng)性率為82.7%(81/98),與臨床分期、病理分級(jí)和淋巴結(jié)轉(zhuǎn)移相關(guān)(P0.05);FAP在子宮頸浸潤(rùn)性癌間質(zhì)中的陽(yáng)性率為79.6%(78/98),FAP表達(dá)與子宮頸浸潤(rùn)性癌的臨床分期、病理分級(jí)和淋巴結(jié)轉(zhuǎn)移相關(guān)(P0.05);α-SMA和FAP均與患者年齡、腫瘤大小無關(guān)(P0.05)。α-SMA和FAP在子宮頸浸潤(rùn)性癌組織標(biāo)本中表達(dá)在區(qū)域上有一致性,在表達(dá)強(qiáng)度上呈明顯正相關(guān)。經(jīng)直線相關(guān)分析α-SMA和FAP呈直線相關(guān)(r=0.829,P=0.000)。結(jié)論α-SMA和FAP在子宮頸浸潤(rùn)性癌生長(zhǎng)、浸潤(rùn)和轉(zhuǎn)移方面發(fā)揮一定作用,可作為預(yù)測(cè)子宮頸浸潤(rùn)性癌預(yù)后的可靠指標(biāo)。
[Abstract]:Objective to investigate the expression of 偽 -smooth muscle actin (偽 -SMA) and fibroblast-activating protein in normal cervix, cervical intraepithelial neoplasia (cervical intraepithelial neoplasias cin) and invasive cervical carcinoma. The relationship between the expression and clinicopathological parameters, invasion and metastasis and prognosis of invasive cervical carcinoma was analyzed. Methods the expression of 偽 -SMA and FAP in 20 cases of normal cervical carcinoma and 98 cases of invasive carcinoma of cervix were detected by immunohistochemical Eli Vision two-step method. To compare the expression of 偽 -SMA and FAP in the three groups and their correlation with the clinicopathological features of invasive cervical carcinoma. Results 偽 -SMA and FAP were not expressed in cin of normal cervical carcinoma. Both of them were expressed in the cytoplasm of the interstitial fibroblasts of cervical carcinoma. The positive rate of 偽 -SMA was 82.7% (81 / 98), and the positive rate of 偽 -SMA was 82.7% (81 / 98), and the positive rate of 偽 -SMA was 82.7% (81 / 98) in the stroma of cervical invasive carcinoma, and the positive rate of 偽 -SMA was 82.7% (81 / 98), which was correlated with the clinical stage. Pathological grade and lymph node metastasis correlated (P0.05) the positive rate of FAP was 79.6% (78 / 98) in the interstitial of invasive carcinoma of the cervix and correlated with clinical stage, pathological grade and lymph node metastasis (P0.05), 偽 -SMA and FAP were correlated with the age of the patients. There was no significant difference in tumor size (P0.05). 偽 -SMA and FAP expression were consistent in the region and positively correlated with the expression intensity in invasive cervical carcinoma. The linear correlation between 偽 -SMA and FAP was linear (r = 0.829, P = 0.000). Conclusion 偽 -SMA and FAP may play a certain role in the growth, invasion and metastasis of invasive cervical carcinoma, and can be used as a reliable index to predict the prognosis of invasive cervical carcinoma.
【作者單位】： 吉林省通化市人民醫(yī)院病理科;北華大學(xué)基礎(chǔ)醫(yī)學(xué)院病理教研室;
【分類號(hào)】：R737.33

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