【摘要】：目的：通過復(fù)習(xí)卵巢惡性性索間質(zhì)腫瘤的臨床病理特征探討其診治策略。 方法：回顧性收集浙江大學(xué)醫(yī)學(xué)院附屬婦產(chǎn)科醫(yī)院1998年5月-2013年8月收治的101例卵巢惡性性索間質(zhì)腫瘤患者的臨床病理資料及預(yù)后情況。 結(jié)果：卵巢惡性性索間質(zhì)腫瘤的發(fā)病年齡為8-78歲,中位年齡47.50歲。49.5%患者因陰道不規(guī)則出血就診,其次為發(fā)現(xiàn)盆腔包塊、腹痛、閉經(jīng)、不孕。24例(23.76%)患者行保留生育功能手術(shù),其中13例為Ia期,11例為Ic期。根據(jù)術(shù)后病理結(jié)果Ⅰ期患者有99例(98.02%),Ⅱ期和Ⅲ期均1例(0.99%)。所有淋巴結(jié)切除者均未見轉(zhuǎn)移。26.67%患者合并子宮內(nèi)膜病變,其中4%為子宮內(nèi)膜癌。術(shù)后44例患者輔助化療,隨訪的69例患者均存活,其中1例患者復(fù)發(fā)后行腫瘤減滅術(shù)。 結(jié)論：卵巢惡性性索間質(zhì)腫瘤多發(fā)生于圍絕經(jīng)期,發(fā)現(xiàn)時多為Ⅰ期,絕大多數(shù)為單純或混合顆粒細(xì)胞瘤,預(yù)后良好。Ⅰ期低�；颊呖刹恍辛馨徒Y(jié)切除,年輕患者可保留生育功能手術(shù),但建議行子宮內(nèi)膜診刮或活檢。
[Abstract]:Objective: To explore the diagnosis and treatment strategy of ovarian malignant stromal tumors by reviewing the clinicopathological features.
Methods: the clinicopathological data and prognosis of 101 cases of ovarian malignant stromal tumors admitted in the Department of Obstetrics and Gynecology, affiliated to the Medical College of Zhejiang University, in August -2013 May 1998, were retrospectively reviewed.
Results: the age of the malignant stromal tumor of the ovary was 8-78 years old. The median age of 47.50 years old.49.5% patients was diagnosed with irregular vaginal bleeding. The second was to find pelvic mass, abdominal pain, amenorrhea, and infertility (23.76%) of the.24 patients (23.76%), of which 13 were Ia and 11 were Ic. According to the postoperative pathological results, there were 99 patients. Cases (98.02%), stage II and stage III were all 1 cases (0.99%). None of the patients with metastatic.26.67% had endometrial lesions, of which 4% were endometrial carcinoma. 44 patients received adjuvant chemotherapy after operation, and 69 patients were all survived, 1 of whom underwent swelling and subtraction after recurrence.
Conclusion: ovarian malignant stromal tumors mostly occur in perimenopausal period, most of which are stage I, and most of them are simple or mixed granulosa cell tumor, and the prognosis is good.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.31

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