【摘要】：目的：分析妊娠期間碘營養(yǎng)、甲狀腺自身抗體與甲狀腺功能的關(guān)系。 方法：電化學發(fā)光法檢測140名妊娠女性甲狀腺功能及甲狀腺過氧化物酶抗體（TPOAb）、甲狀腺球蛋白抗體（TgAb）水平，根據(jù)血清促甲狀腺激素（TSH）及游離甲狀腺素（FT4）水平分為正常組(n=117)和亞臨床甲狀腺功能減退組(n=23)。甲狀腺觸診了解是否甲狀腺腫。應用尿碘砷鈰催化分光光度法檢測孕婦尿碘水平。調(diào)查甲狀腺功能異常組既往甲狀腺病史知曉情況。使用EXCEL軟件收集數(shù)據(jù)，應用SPSS19.0對數(shù)據(jù)進行分析。 結(jié)果：①正常組與亞臨床甲狀腺功能減退組分別有50%、57%的女性具有不同程度碘缺乏。②尿碘水平與甲狀腺功能無顯著相關(guān)。③血清TPOAb、TgAb水平與血清TSH顯著相關(guān)，TPOAb水平與血清FT4顯著相關(guān)。④甲狀腺功能異常者中70%孕前未行甲狀腺功能及自身抗體篩查，8.7%否認既往甲狀腺疾病史，21.7%既往有甲狀腺功能減退。 結(jié)論：甲狀腺自身抗體為亞臨床甲狀腺功能減退發(fā)生的主要危險因素，支持孕前或孕早期常規(guī)篩查尿碘及甲狀腺自身抗體,及時糾正碘缺乏，，并避免盲目過量補碘，改善圍產(chǎn)期結(jié)局，以減少對親子的不利影響。
[Abstract]:Objective: to analyze the relationship between iodine nutrition, thyroid autoantibodies and thyroid function during pregnancy. Methods: the thyroid function of 140 pregnant women and the level of thyroid peroxidase antibody (TPOAb),) thyroglobulin antibody (TgAb) were detected by electrochemiluminescence (ECL). According to the levels of serum thyrotropin (TSH) and free thyroxine (FT4), they were divided into normal group and subclinical hypothyroidism group. Thyroid palpation to see if goiter. Urine iodine level of pregnant women was determined by catalytic spectrophotometry with iodide, arsenic and cerium. To investigate the knowledge of thyroid history in patients with abnormal thyroid function. EXCEL software is used to collect data and SPSS19.0 is used to analyze the data. Results there was no significant correlation between urinary iodine deficiency and thyroid function. 3 serum TPO Ab level and serum TSH level in 50% of women with normal and subclinical hypothyroidism. There was a significant correlation between serum FT4 and thyroid function in 70% of the patients with abnormal thyroid function before pregnancy and 8. 7% of them denied that there was a history of thyroid disease and 21. 7% had past hypothyroidism. Conclusion: thyroid autoantibodies are the main risk factors for subclinical hypothyroidism, which supports routine screening of urinary iodine and thyroid autoantibodies before pregnancy or early pregnancy, in order to correct iodine deficiency in time and avoid blind overdose of iodine. Improve perinatal outcomes to reduce adverse effects on parentage.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R714.256

【參考文獻】

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1 李晨陽,滕衛(wèi)平,尚濤;甲狀腺激素與妊娠[J];中華內(nèi)分泌代謝雜志;2003年02期

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