隨機(jī)尿微量白蛋白與尿肌酐比值在妊娠高血壓疾病早期腎損傷的臨床應(yīng)用
發(fā)布時(shí)間：2018-07-27 21:27
【摘要】：目的:探討隨機(jī)尿微量白蛋白與尿肌酐比值(UACR)在妊娠高血壓疾病早期腎損傷中的應(yīng)用價(jià)值,制定輕度和重度子癇前期(PE)的隨機(jī)UACR參考值。方法:選取2013年1月至2014年7月在我院住院的妊娠期高血壓疾病患者148例(妊娠期高血壓48例,輕度PE患者55例,重度PE患者45例),正常晚孕期孕婦30例,測(cè)定隨機(jī)UACR、24h尿蛋白定量,進(jìn)行相關(guān)性分析。應(yīng)用受試者工作曲線,確定UACR對(duì)應(yīng)于24h尿蛋白0.3g及2.0g時(shí)的診斷界值。結(jié)果:妊娠期高血壓組、輕度PE組、重度PE組及正常晚孕組的平均24h尿蛋白分別為(114.91±52.31)mg/24h、(779.12±540.85)mg/24h、(4159.55±1719.69)mg/24h、(80.05±29.68)mg/24h,隨機(jī)UACR分別為(16.91±7.76)mg/mmol、(75.20±38.10)mg/mmol、(486.78±202.73)mg/mmol、(1.42±0.45)mg/mmol。妊娠期高血壓組的24h尿蛋白定量與正常晚孕組比較,無(wú)顯著差異(P0.05),其余各組兩兩比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05);各組的隨機(jī)UACR比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。妊娠期高血壓疾病患者的隨機(jī)UACR與24h尿蛋白定量呈高度線性相關(guān)(r=0.929,P0.001)。24h尿蛋白定量為0.3g和2.0g時(shí)對(duì)應(yīng)的隨機(jī)UACR值分別為32.85mg/mmol和174.5mg/mmol。結(jié)論:隨機(jī)UACR與24h尿蛋白定量有高度相關(guān)性,檢測(cè)隨機(jī)UACR可用于及早發(fā)現(xiàn)妊娠期高血壓疾病的早期腎損傷;隨機(jī)UACR有望代替24h尿蛋白定量作為判斷妊娠高血壓疾病病情嚴(yán)重程度的評(píng)估指標(biāo);隨機(jī)UACR的最佳診斷界值需更大樣本量的研究支持。
[Abstract]:Objective: to investigate the value of random urinary microalbumin to urinary creatinine ratio (UACR) in renal injury in the early stage of pregnancy-induced hypertension, and to establish the random UACR reference value for mild and severe preeclampsia (PE). Methods: 148 cases of hypertensive disorder complicating pregnancy (48 cases of hypertension complicating pregnancy, 55 cases of mild PE and 45 cases of severe PE) were selected from January 2013 to July 2014 in our hospital. The 24-hour urine protein of random UACRs was measured and the correlation was analyzed. Using the operating curve of subjects, the diagnostic threshold of UACR corresponding to 0.3 g and 2.0 g of 24 h urinary protein was determined. Results: the mean 24 h urinary protein levels in hypertensive complicating pregnancy group, mild PE group, severe PE group and normal late pregnancy group were (114.91 鹵52.31) mg / r 24 h, (779.12 鹵540.85) mg / r 24 h, (4159.55 鹵1719.69) mg / r 24 h, (80.05 鹵29.68) mg / r 24 h, and (16.91 鹵7.76) mg / mol, (75.20 鹵38.10) mg / mol, (486.78 鹵202.73) mg / mol, (1.42 鹵0.45) mg / mol, respectively. There was no significant difference in 24 hours urine protein between gestational hypertension group and normal late pregnancy group (P0.05), while the other two groups had statistical significance (P0.05); the random UACR of each group had statistical significance (P0.05). There was a high linear correlation between random UACR and 24-hour urinary protein quantification in hypertensive disorder complicating pregnancy (r = 0.929, P0.001). The corresponding random UACR values were 32.85mg/mmol and 174.5 mg / mmol. when 24h urinary protein quantification was 0.3 g and 2.0 g, respectively. Conclusion: there is a high correlation between random UACR and 24 hours urinary protein quantification. The detection of random UACR can be used to detect early renal injury in hypertensive disorder complicating pregnancy. Random UACR may be used as an index to evaluate the severity of pregnancy-induced hypertension in place of 24h urinary protein quantification, and the optimal diagnostic threshold of random UACR should be supported by a larger sample size.
【作者單位】： 廣東省東莞市橫瀝醫(yī)院婦產(chǎn)科;
【基金】：東莞市科技計(jì)劃醫(yī)療衛(wèi)生類科研一般項(xiàng)目(No:201310515000371)
【分類號(hào)】：R714.246
[Abstract]:Objective: to investigate the value of random urinary microalbumin to urinary creatinine ratio (UACR) in renal injury in the early stage of pregnancy-induced hypertension, and to establish the random UACR reference value for mild and severe preeclampsia (PE). Methods: 148 cases of hypertensive disorder complicating pregnancy (48 cases of hypertension complicating pregnancy, 55 cases of mild PE and 45 cases of severe PE) were selected from January 2013 to July 2014 in our hospital. The 24-hour urine protein of random UACRs was measured and the correlation was analyzed. Using the operating curve of subjects, the diagnostic threshold of UACR corresponding to 0.3 g and 2.0 g of 24 h urinary protein was determined. Results: the mean 24 h urinary protein levels in hypertensive complicating pregnancy group, mild PE group, severe PE group and normal late pregnancy group were (114.91 鹵52.31) mg / r 24 h, (779.12 鹵540.85) mg / r 24 h, (4159.55 鹵1719.69) mg / r 24 h, (80.05 鹵29.68) mg / r 24 h, and (16.91 鹵7.76) mg / mol, (75.20 鹵38.10) mg / mol, (486.78 鹵202.73) mg / mol, (1.42 鹵0.45) mg / mol, respectively. There was no significant difference in 24 hours urine protein between gestational hypertension group and normal late pregnancy group (P0.05), while the other two groups had statistical significance (P0.05); the random UACR of each group had statistical significance (P0.05). There was a high linear correlation between random UACR and 24-hour urinary protein quantification in hypertensive disorder complicating pregnancy (r = 0.929, P0.001). The corresponding random UACR values were 32.85mg/mmol and 174.5 mg / mmol. when 24h urinary protein quantification was 0.3 g and 2.0 g, respectively. Conclusion: there is a high correlation between random UACR and 24 hours urinary protein quantification. The detection of random UACR can be used to detect early renal injury in hypertensive disorder complicating pregnancy. Random UACR may be used as an index to evaluate the severity of pregnancy-induced hypertension in place of 24h urinary protein quantification, and the optimal diagnostic threshold of random UACR should be supported by a larger sample size.
【作者單位】： 廣東省東莞市橫瀝醫(yī)院婦產(chǎn)科;
【基金】：東莞市科技計(jì)劃醫(yī)療衛(wèi)生類科研一般項(xiàng)目(No:201310515000371)
【分類號(hào)】：R714.246
【共引文獻(xiàn)】
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