除濕止帶方聯(lián)合干擾素治療濕熱下注型宮頸高危型HPV感染的臨床研究
發(fā)布時(shí)間：2018-07-25 08:48
【摘要】：目的：通過觀察除濕止帶方聯(lián)合干擾素治療濕熱下注型宮頸高危型人乳頭瘤病毒(high risk human papilloma viruses, HR-HPV)感染的臨床療效,尋求有效的中藥組方治療宮頸HR-HPV感染,有效防治宮頸癌的發(fā)生。方法：采用隨機(jī)對照研究方法,納入符合濕熱下注型HR-HPV感染的病例80例,并隨機(jī)分為治療組和對照組,治療組病例40例,對照組病例40例。治療組選除濕止帶方聯(lián)合干擾素陰道上藥治療,對照組采用干擾素陰道上藥,于月經(jīng)干凈后3天開始治療,每周期連續(xù)治療14天,共治療三個(gè)月經(jīng)周期。觀察比較兩組的證候積分變化、HR-HPV轉(zhuǎn)陰情況、白帶清潔度以及安全性指標(biāo),并進(jìn)行統(tǒng)計(jì)學(xué)分析,比較不同治療方法的臨床療效。結(jié)果：1.研究顯示兩組患者治療后各證候積分及總積分與治療前比較,差異有統(tǒng)計(jì)學(xué)意義,兩種治療方案均能改善各證候。2.治療組和對照組的中醫(yī)臨床證候療效有統(tǒng)計(jì)學(xué)差異(Z=-3.841,P=0.000),提示治療組在改善患者臨床證候方面,療效明顯優(yōu)于對照組。3.治療組HPV轉(zhuǎn)陰率為55.0%,對照組轉(zhuǎn)陰率為32.5%,χ2=4.114,P=0.043,差異有統(tǒng)計(jì)學(xué)意義,提示治療組對HR-HPV感染轉(zhuǎn)陰效果優(yōu)于對照組。4.對比HPV33、HPV52、HPV58及其它9項(xiàng)高危型HPV四種常見病理分型的轉(zhuǎn)陰情況,經(jīng)分層卡方檢驗(yàn),結(jié)果顯示治療組和對照組治療不同病理分型的宮頸HR-HPV感染的療效相當(dāng)。5.對比兩組治療后白帶清潔度情況,結(jié)果無統(tǒng)計(jì)學(xué)差異(Z=-0.325,P=0.745),說明在改善白帶清潔度方面,兩組療效相當(dāng)。6.治療過程中,所有受試者均未出現(xiàn)不良事件,且安全性指標(biāo)均未見明顯異常變化。結(jié)論：1.對濕熱下注型宮頸HR-HPV感染的患者采用除濕止帶方聯(lián)合干擾素治療,能顯著改善患者臨床證候,提高宮頸HR-HPV感染轉(zhuǎn)陰率。2.除濕止帶方聯(lián)合干擾素治療宮頸HR-HPV感染,療效優(yōu)于單純運(yùn)用干擾素。
[Abstract]:Objective: to observe the clinical curative effect of dehumidification Zhizhuangfang combined with interferon in the treatment of high risk human papillomavirus (high risk human papilloma viruses, HR-HPV) infection of cervix with dampness and heat, and to seek an effective prescription for the treatment of cervical HR-HPV infection and the prevention and treatment of cervical cancer. Methods: a randomized controlled study was conducted in 80 patients with HR-HPV infection according to damp-heat betting type, and were randomly divided into two groups: treatment group (n = 40) and control group (n = 40). In the treatment group, the treatment group was treated with the prescription of removing dampness and Zhibanfang combined with interferon vagina, while the control group was treated with interferon vagina. The treatment began on 3 days after menstruation was clean, and was treated continuously for 14 days in each cycle for three menstrual cycles. To observe and compare the changes of syndromes integral changes of HR-HPV, leucorrhea cleanliness and safety index, and to compare the clinical efficacy of different treatment methods. The result is 1: 1. The study shows that the difference between the two groups after treatment and before treatment is statistically significant, the two treatment schemes can improve the symptoms of each syndrome. 2. The curative effect of TCM syndromes in treatment group and control group was statistically different (ZHI-3.841PU 0.000), which indicated that the therapeutic effect of treatment group was obviously better than that of control group in improving the clinical syndrome of patients. The negative conversion rate of HPV in the treatment group was 55.0 and that in the control group was 32.5. The difference was statistically significant. It suggested that the negative conversion of HR-HPV infection in the treatment group was better than that in the control group. The four common pathological types of HPV33, HPV52, HPV58 and 9 other high-risk types of HPV were compared. The results of stratified chi-square test showed that the therapeutic effect of treatment group and control group on cervical HR-HPV infection of different pathological types was equal to that of control group. There was no statistical difference between the two groups in the cleanliness of leucorrhoea after treatment (ZC- 0.325 P0. 745), which indicated that the effect of the two groups in improving the leucorrhea cleanliness was equivalent to. 6. 6. In the course of treatment, no adverse events were found in all subjects, and no obvious abnormal changes in safety indices were observed. Conclusion 1. The treatment of dampness and heat betting type of cervix HR-HPV infection with dehumidification and zhizongfang combined with interferon can significantly improve the clinical symptoms of the patients and increase the negative rate of cervical HR-HPV infection. 2. The therapeutic effect of dehumidification and interferon on cervical HR-HPV infection is better than that of interferon alone.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R737.33
本文編號：2143277
[Abstract]:Objective: to observe the clinical curative effect of dehumidification Zhizhuangfang combined with interferon in the treatment of high risk human papillomavirus (high risk human papilloma viruses, HR-HPV) infection of cervix with dampness and heat, and to seek an effective prescription for the treatment of cervical HR-HPV infection and the prevention and treatment of cervical cancer. Methods: a randomized controlled study was conducted in 80 patients with HR-HPV infection according to damp-heat betting type, and were randomly divided into two groups: treatment group (n = 40) and control group (n = 40). In the treatment group, the treatment group was treated with the prescription of removing dampness and Zhibanfang combined with interferon vagina, while the control group was treated with interferon vagina. The treatment began on 3 days after menstruation was clean, and was treated continuously for 14 days in each cycle for three menstrual cycles. To observe and compare the changes of syndromes integral changes of HR-HPV, leucorrhea cleanliness and safety index, and to compare the clinical efficacy of different treatment methods. The result is 1: 1. The study shows that the difference between the two groups after treatment and before treatment is statistically significant, the two treatment schemes can improve the symptoms of each syndrome. 2. The curative effect of TCM syndromes in treatment group and control group was statistically different (ZHI-3.841PU 0.000), which indicated that the therapeutic effect of treatment group was obviously better than that of control group in improving the clinical syndrome of patients. The negative conversion rate of HPV in the treatment group was 55.0 and that in the control group was 32.5. The difference was statistically significant. It suggested that the negative conversion of HR-HPV infection in the treatment group was better than that in the control group. The four common pathological types of HPV33, HPV52, HPV58 and 9 other high-risk types of HPV were compared. The results of stratified chi-square test showed that the therapeutic effect of treatment group and control group on cervical HR-HPV infection of different pathological types was equal to that of control group. There was no statistical difference between the two groups in the cleanliness of leucorrhoea after treatment (ZC- 0.325 P0. 745), which indicated that the effect of the two groups in improving the leucorrhea cleanliness was equivalent to. 6. 6. In the course of treatment, no adverse events were found in all subjects, and no obvious abnormal changes in safety indices were observed. Conclusion 1. The treatment of dampness and heat betting type of cervix HR-HPV infection with dehumidification and zhizongfang combined with interferon can significantly improve the clinical symptoms of the patients and increase the negative rate of cervical HR-HPV infection. 2. The therapeutic effect of dehumidification and interferon on cervical HR-HPV infection is better than that of interferon alone.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R737.33
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