【摘要】：目的:探討在不同月經(jīng)周期子宮內(nèi)膜異位癥頸體結(jié)合及宮底部子宮結(jié)合帶中OTR的表達(dá)水平研究。方法:收取因子宮內(nèi)膜異位癥行子宮切除術(shù)的頸體結(jié)合及宮底部子宮結(jié)合帶蠟塊組織21例為觀察組,其中增生期16例,分泌期5例。收集同期因?qū)m頸癌、卵巢癌或?qū)m頸上皮內(nèi)瘤變III行子宮切除術(shù)的患者子宮結(jié)合帶蠟塊組織48例為對(duì)照組,其中增生期26例,分泌期22例。采用免疫組織化學(xué)方法檢測(cè)各組子宮結(jié)合帶組織中OTR的表達(dá)水平。結(jié)果:OTR表達(dá)在實(shí)驗(yàn)組和對(duì)照組JZ平滑肌細(xì)胞質(zhì)中。在正常的子宮中,增生期頸體部位子宮結(jié)合帶OTR表達(dá)高于宮底部位(p0.05),分泌期頸體部位子宮結(jié)合帶OTR表達(dá)低于宮底部位(p0.05)。無論是頸體部位還是宮底部位,增生期OTR的表達(dá)高于分泌期(p0.05)。無論是增生期還是分泌期,EMT頸體部位OTR的水平與宮底部OTR無統(tǒng)計(jì)學(xué)差異(p0.05)。無論在頸體還是宮底部位,EMT增生期與分泌期OTR水平無統(tǒng)計(jì)學(xué)差異(p0.05)。r ASRM I期和II期宮底部位子宮結(jié)合帶縮宮素受體表達(dá)低于r ASRM III期和IV期(p0.05)。卵巢型子宮內(nèi)膜異位癥宮底部位子宮結(jié)合帶OTR的表達(dá)低于深部結(jié)節(jié)型子宮內(nèi)膜異位癥宮底部子宮結(jié)合帶OTR的水平(p0.05)。宮底部OTR的表達(dá)水平與痛經(jīng)的程度成正相關(guān)(r=0.872,p0.05)。與正常子宮相比,分泌期頸體與宮底OTR水平表達(dá)升高(p0.05)。無論是增生期還是分泌期,EMT宮底部位子宮結(jié)合帶OTR的水平表達(dá)均高于正常子宮(p0.05)。結(jié)論:子宮內(nèi)膜異位癥子宮結(jié)合OTR有異常表達(dá)現(xiàn)象,可能會(huì)導(dǎo)致子宮的異常收縮,引起痛經(jīng)和生育力的下降。
[Abstract]:Aim: to investigate the expression of OTR in cervical body binding and uterine binding zone of endometriosis in different menstrual cycles. Methods: a total of 21 cases of cervical-body binding and uterine binding with waxed tissue were collected from 21 cases of endometriosis treated by hysterectomy, including 16 cases in proliferative phase and 5 cases in secretory phase. A total of 48 cases of uterine binding waxy tissue were collected as the control group, including 26 cases in proliferative phase and 22 cases in secretory phase, who underwent hysterectomy due to cervical cancer, ovarian cancer or cervical intraepithelial neoplasia III. The expression of OTR in uterine binding zone was detected by immunohistochemical method. Results OTR was expressed in the JZ smooth muscle cytoplasm of the experimental group and the control group. In normal uterus, the expression of OTR in uterine binding zone in proliferative cervical body was higher than that in subuterine floor (p0.05), and the expression of OTR in uterine binding zone in secretory cervical body was lower than that in subuterine floor (p0.05). The expression of OTR in proliferative phase was higher than that in secretory phase (p0.05). There was no significant difference between the level of OTR in the cervical body of EMT and the OTR in the fundus of the uterus in proliferative or secretory phase (p0.05). There was no significant difference in the level of OTR between proliferative and secretory phases of EMT in the cervical body and the fundus of uterus (p0.05). The expression of oxytocin receptor in uterine binding zone in stage I and II was lower than that in stage III and IV (p0.05). The expression of OTR in uterine binding zone of ovarian endometriosis was lower than that in deep nodular endometriosis (p0.05). The expression of OTR in the fundus of uterus was positively correlated with the degree of dysmenorrhea (r 0.872p0.05). Compared with normal uterus, the expression of OTR in cervical and fundus during secretory phase was higher than that in normal uterus (p0.05). The expression of OTR in uterine binding zone of EMT was higher than that in normal uterus (p0.05). Conclusion: the abnormal expression of OTR in endometriosis may lead to abnormal contraction of uterus and decrease of dysmenorrhea and fertility.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R711.71

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