發(fā)布時(shí)間：2018-07-11 12:32

  本文選題：青春期多囊卵巢綜合征 + 胰島素抵抗　； 參考：《南京中醫(yī)藥大學(xué)》2014年碩士論文

【摘要】：目的：通過(guò)對(duì)中醫(yī)藥干預(yù)青春期多囊卵巢綜合征的大樣本病例研究,探索早期干預(yù)青春期多囊卵巢綜合征的中醫(yī)治療方案。 方法：收集接受中藥治療的青春期多囊卵巢綜合征患者,根據(jù)患者有無(wú)胰島素抵抗分為兩個(gè)隊(duì)列,其中胰島素抵抗組72例,非胰島素抵抗組75例。分別用溫腎化痰法、補(bǔ)腎調(diào)周法進(jìn)行干預(yù),其中年齡范圍在15-19歲,病程最短6月,最長(zhǎng)3年。觀察和比較兩組治療前后月經(jīng)情況、體重指數(shù)(BMI)、血清黃體生成素(LH)、卵泡刺激素(FSH)、LH/FSH,睪酮(T)、空腹血糖(FPG)、空腹胰島素(FINS)水平、穩(wěn)態(tài)模型評(píng)估(HOMA-IR)等指標(biāo)。 結(jié)果：胰島素抵抗組治療前后月經(jīng)周期有顯著差異(P0.05),治療后周期較前明顯縮短。LH, LH/FSH, T均下降,差異有顯著性(P0.05),而FSH前后自身比較,均無(wú)統(tǒng)計(jì)學(xué)差異(P值為0.4410.05)。BMI治療前后組內(nèi)自身比較,P0.05,提示差異有顯著性,治療后FPG自身比較無(wú)統(tǒng)計(jì)學(xué)差異(P為0.1650.05), FINS、HOMA-IR較治療前比較有顯著降低(P0.01)。非胰島素抵抗組治療前后月經(jīng)周期有顯著差異(P0.05),治療后周期較前明顯縮短。治療后LH, LH/FSH, T均下降,差異有顯著性(P0.05), FSH前后自身比較,無(wú)統(tǒng)計(jì)學(xué)差異(P值為0.7920.05)。治療后FPG、FINS、HOMA-IR自身比較無(wú)顯著差異(P分別為0.265、0.096、0.224,P均0.05)。 結(jié)論：中醫(yī)藥能有效治療青春期多囊卵巢綜合征。其中,溫腎化痰法能顯著改善胰島素抵抗組患者的月經(jīng)周期,降低LH、LH/FSH比值、T水平(P0.05),改善患者的胰島素抵抗,降低FINS、HOMA-IR水平(P0.05),并可以有效改善患者肥胖狀態(tài),降低BMI值。補(bǔ)腎調(diào)周法能夠改善非胰島素抵抗組患者的月經(jīng)周期,對(duì)于降低LH、LH/FSH比值、T水平(P0.05)療效確切。
[Abstract]:Objective: to explore the treatment scheme of early intervention of puberty polycystic ovary syndrome (PCOS) by a large sample of Chinese medicine (TCM) intervention in pubertal polycystic ovary syndrome (PCOS). Methods: the patients with puberty polycystic ovary syndrome (PCOS) treated with traditional Chinese medicine were divided into two cohorts according to whether they had insulin resistance (n = 72) and non-insulin resistance (n = 75). The methods of warming kidney and resolving phlegm and tonifying kidney and regulating week were used to intervene. The age range was 15-19 years, the course of disease was shortest 6 months, and the longest was 3 years. Menstruation, body mass index (BMI), serum luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), fasting blood glucose (FPG), fasting insulin (fins) and homeostasis model (HOMA-IR) were observed and compared before and after treatment. Results: there was significant difference in menstrual cycle before and after treatment in insulin resistance group (P0.05). After treatment, the menstrual cycle of insulin resistance group was significantly shorter than that of before and after treatment. LH / FSHT decreased significantly (P0.05), but FSH itself was compared before and after treatment. There was no statistical difference (P = 0.4410.05). There was no significant difference in FPG after treatment (P = 0.1650.05), and FINSHOMA-IR was significantly lower than that before and after treatment (P0.01). There was significant difference in menstrual cycle before and after treatment in non-insulin resistance group (P0.05). After treatment, LH, LH / FSH, T decreased significantly (P0.05), there was no significant difference in FSH before and after treatment (P = 0.7920.05). There was no significant difference in HOMA-IR between the two groups (P = 0.265, 0.096, P < 0.05). Conclusion: Chinese medicine can effectively treat pubertal polycystic ovary syndrome. The method of warming kidney and resolving phlegm can significantly improve the menstrual cycle, decrease the ratio of LHH / FSH to T (P0.05), improve the insulin resistance and decrease the level of FINSHOMA-IR (P0.05), and can effectively improve the obesity status of the patients and reduce the BMI value. The method of tonifying kidney and regulating week can improve the menstrual cycle of patients with non-insulin resistance, and it is effective to reduce the ratio of LHH / FSH to T (P0.05).
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R711.75

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本文編號(hào)：2115209