本文選題：雙酚A(BPA) + 卵泡液��； 參考：《生殖與避孕》2016年07期

【摘要】：目的:探討卵泡液中雙酚A(bisphenol A,BPA)在多囊卵巢綜合征(PCOS)發(fā)病中的作用。方法:于取卵日收集行體外受精/卵胞質(zhì)內(nèi)單精子顯微注射(IVF/ICSI)的PCOS患者和非PCOS患者的卵泡液,檢測(cè)患者卵泡液BPA水平和卵泡液性激素水平,并進(jìn)一步與患者血清抗苗勒氏管激素(AMH)及臨床結(jié)局等因素行相關(guān)性分析。結(jié)果:PCOS患者和非PCOS患者的卵泡液BPA水平(446.57±63.57 ng/L vs 336.29±59.02 ng/L,P0.001)、血清AMH水平(12.09±4.78μg/L vs5.69±2.98μg/L,P0.001)、卵泡液FSH(5.58±1.66 IU/L vs 3.95±1.54 IU/L,P=0.008)、LH(4.54±2.97 IU/L vs 0.96±1.10 IU/L,P0.001)和T(54.68±34.34 nmol/L vs 32.48±16.68 nmol/L,P=0.035)組間比較有統(tǒng)計(jì)學(xué)差異。相關(guān)性分析顯示,卵泡液中BPA水平與血清AMH水平呈顯著正相關(guān)(r=0.577,P=0.001)。結(jié)論:卵巢局部的BPA暴露可能參與了PCOS疾病的發(fā)生、發(fā)展。
[Abstract]:Objective: to investigate the role of bisphenol A (bisphenol A) in the pathogenesis of polycystic ovary syndrome (PCOS). Methods: follicular fluid was collected from PCOS patients and non-PCOS patients who underwent in vitro fertilization / intracytoplasmic sperm microinjection (IVF / ICSI) on the day of in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI). The relationship between AMH and clinical outcome was analyzed. 緇撴灉:PCOS鎮(zhèn)ｈ，

本文編號(hào)：2099235